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- NCIT_C155775 IAO_0000115 "Autologous peripheral blood mononuclear cells (PBMCs) transfected with anti-mesothelin chimeric antigen receptor (CAR) mRNA, with potential antineoplastic activity. Upon intraperitoneal (IP) administration, the autologous mesothelin-specific human mRNA CAR-transfected PBMCs MCY-M11 recognize, bind to, phagocytose and directly kill cancer cells expressing mesothelin. In addition, MCY-M11 stimulates the immune system to induce a cytotoxic T-lymphocyte response against the mesothelin-expressing cancer cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in many epithelial-derived cancers." @default.
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- NCIT_C155775 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155775 NCIT_P107 "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11" @default.
- NCIT_C155775 NCIT_P108 "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11" @default.
- NCIT_C155775 NCIT_P208 "CL556250" @default.
- NCIT_C155775 NCIT_P319 "ER09HM7LIR" @default.
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- NCIT_C155775 NCIT_P329 "794988" @default.
- NCIT_C155775 NCIT_P330 "794988" @default.
- NCIT_C155775 NCIT_P375 "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11" @default.
- NCIT_C155775 NCIT_P399 "794988" @default.
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- NCIT_C155775 hasExactSynonym "Anti-mesothelin mRNA-transfected Autologous PBMCs MCY-M11" @default.
- NCIT_C155775 hasExactSynonym "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11" @default.
- NCIT_C155775 hasExactSynonym "MCY-M11" @default.
- NCIT_C155775 inSubset NCIT_C116977 @default.
- NCIT_C155775 inSubset NCIT_C116978 @default.
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- NCIT_C155775 inSubset NCIT_C176424 @default.
- NCIT_C155775 inSubset NCIT_C177537 @default.
- NCIT_C155775 inSubset NCIT_C63923 @default.
- NCIT_C155775 type Class @default.
- NCIT_C155775 isDefinedBy ncit.owl @default.
- NCIT_C155775 label "Autologous Mesothelin-specific Human mRNA CAR-transfected PBMCs MCY-M11" @default.
- NCIT_C155775 subClassOf NCIT_C155775 @default.
- NCIT_C155775 subClassOf NCIT_C1908 @default.
- NCIT_C155775 subClassOf NCIT_C1909 @default.
- NCIT_C155775 subClassOf NCIT_C307 @default.
- NCIT_C155775 subClassOf NCIT_C308 @default.