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- NCIT_C155794 IAO_0000115 "An antibody-drug conjugate (ADC) composed of a cysteine-engineered version of epratuzumab (hLL2), a humanized anti-CD22 monoclonal antibody derived from the murine immunoglobulin (Ig) G2a monoclonal antibody LL2 (EPB-2), site-specifically conjugated to the cross-linking cytotoxic agent tesirine (SG3249), a cathepsin B-cleavable valine-alanine pyrrolobenzodiazepine dimer (PBD), with potential antineoplastic activity. Upon administration of epratuzumab-cys-tesirine, the epratuzumab moiety targets and binds to the B cell-specific CD22 receptor and is rapidly internalized. Upon cleavage, the imine groups of tesirine target and bind to the N2 positions of guanines on opposite strands of DNA. This induces interstrand cross-links in the minor groove of DNA and inhibits DNA replication, which inhibits the proliferation of CD22-overexpressing tumor cells. CD22, a cell surface glycoprotein, is expressed on mature B-cells and on most malignant B-cells." @default.
- NCIT_C155794 NCIT_A32 NCIT_C1909 @default.
- NCIT_C155794 NCIT_A7 NCIT_C17279 @default.
- NCIT_C155794 NCIT_NHC0 "C155794" @default.
- NCIT_C155794 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C155794 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C155794 NCIT_P107 "Epratuzumab-cys-tesirine" @default.
- NCIT_C155794 NCIT_P108 "Epratuzumab-cys-tesirine" @default.
- NCIT_C155794 NCIT_P208 "CL556329" @default.
- NCIT_C155794 NCIT_P319 "7X6143A60Y" @default.
- NCIT_C155794 NCIT_P322 "CTRP" @default.
- NCIT_C155794 NCIT_P322 "FDA" @default.
- NCIT_C155794 NCIT_P322 "GDC" @default.
- NCIT_C155794 NCIT_P329 "794990" @default.
- NCIT_C155794 NCIT_P330 "794990" @default.
- NCIT_C155794 NCIT_P375 "Epratuzumab-cys-tesirine" @default.
- NCIT_C155794 NCIT_P399 "794990" @default.
- NCIT_C155794 normalizedInformationContent "100" @default.
- NCIT_C155794 referenceCount "1" @default.
- NCIT_C155794 hasExactSynonym "ADC ADCT-602" @default.
- NCIT_C155794 hasExactSynonym "ADCT-602" @default.
- NCIT_C155794 hasExactSynonym "ADCT602" @default.
- NCIT_C155794 hasExactSynonym "Anti-CD22/PBD ADC ADCT-602" @default.
- NCIT_C155794 hasExactSynonym "Antibody-drug Conjugate ADCT-602" @default.
- NCIT_C155794 hasExactSynonym "EPRATUZUMAB-CYS-TESIRINE" @default.
- NCIT_C155794 hasExactSynonym "Epratuzumab-cys-SG3249" @default.
- NCIT_C155794 hasExactSynonym "Epratuzumab-cys-tesirine" @default.
- NCIT_C155794 hasExactSynonym "hLL2-cys-PBD" @default.
- NCIT_C155794 hasExactSynonym "hLL2-cys-SG3249" @default.
- NCIT_C155794 inSubset NCIT_C116977 @default.
- NCIT_C155794 inSubset NCIT_C116978 @default.
- NCIT_C155794 inSubset NCIT_C128784 @default.
- NCIT_C155794 inSubset NCIT_C157711 @default.
- NCIT_C155794 inSubset NCIT_C157712 @default.
- NCIT_C155794 inSubset NCIT_C176424 @default.
- NCIT_C155794 inSubset NCIT_C177537 @default.
- NCIT_C155794 inSubset NCIT_C63923 @default.
- NCIT_C155794 type Class @default.
- NCIT_C155794 isDefinedBy ncit.owl @default.
- NCIT_C155794 label "Epratuzumab-cys-tesirine" @default.
- NCIT_C155794 subClassOf NCIT_C129821 @default.
- NCIT_C155794 subClassOf NCIT_C129823 @default.
- NCIT_C155794 subClassOf NCIT_C1512 @default.
- NCIT_C155794 subClassOf NCIT_C155713 @default.
- NCIT_C155794 subClassOf NCIT_C155794 @default.
- NCIT_C155794 subClassOf NCIT_C163758 @default.
- NCIT_C155794 subClassOf NCIT_C1908 @default.
- NCIT_C155794 subClassOf NCIT_C1909 @default.
- NCIT_C155794 subClassOf NCIT_C274 @default.
- NCIT_C155794 subClassOf NCIT_C307 @default.
- NCIT_C155794 subClassOf NCIT_C308 @default.