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- NCIT_C155895 IAO_0000115 "An orally bioavailable, selective inhibitor of the serine/threonine-protein kinase monopolar spindle 1 (Mps1; TTK), with potential antineoplastic activity. Upon administration, the Mps1 inhibitor BOS172722 binds to and inhibits the activity of Mps1, a core component of the spindle assembly checkpoint (SAC). Inhibition of Mps1 activity compromises spindle assembly checkpoint, increases chromosome missegregation errors and decreases cancer cell viability. Mps1, a dual-specificity protein kinase expressed in proliferating normal tissues and aberrantly overexpressed in certain tumor types, is activated during mitosis and is essential in proper SAC function and chromosomal alignment." @default.
- NCIT_C155895 NCIT_A32 NCIT_C1909 @default.
- NCIT_C155895 NCIT_A7 NCIT_C30147 @default.
- NCIT_C155895 NCIT_NHC0 "C155895" @default.
- NCIT_C155895 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155895 NCIT_P108 "Mps1 Inhibitor BOS172722" @default.
- NCIT_C155895 NCIT_P208 "CL562779" @default.
- NCIT_C155895 NCIT_P322 "GDC" @default.
- NCIT_C155895 NCIT_P329 "794872" @default.
- NCIT_C155895 NCIT_P330 "794872" @default.
- NCIT_C155895 NCIT_P375 "Mps1 Inhibitor BOS172722" @default.
- NCIT_C155895 NCIT_P399 "794872" @default.
- NCIT_C155895 normalizedInformationContent "100" @default.
- NCIT_C155895 referenceCount "1" @default.
- NCIT_C155895 hasExactSynonym "BOS 172722" @default.
- NCIT_C155895 hasExactSynonym "BOS172722" @default.
- NCIT_C155895 hasExactSynonym "Monopolar Spindle 1 Inhibitor BOS172722" @default.
- NCIT_C155895 hasExactSynonym "Mps1 Inhibitor BOS172722" @default.
- NCIT_C155895 hasExactSynonym "TTK Inhibitor BOS172722" @default.
- NCIT_C155895 inSubset NCIT_C128784 @default.
- NCIT_C155895 inSubset NCIT_C157711 @default.
- NCIT_C155895 inSubset NCIT_C157712 @default.
- NCIT_C155895 inSubset NCIT_C176424 @default.
- NCIT_C155895 inSubset NCIT_C177537 @default.
- NCIT_C155895 type Class @default.
- NCIT_C155895 isDefinedBy ncit.owl @default.
- NCIT_C155895 label "Mps1 Inhibitor BOS172722" @default.
- NCIT_C155895 subClassOf NCIT_C129824 @default.
- NCIT_C155895 subClassOf NCIT_C129825 @default.
- NCIT_C155895 subClassOf NCIT_C1404 @default.
- NCIT_C155895 subClassOf NCIT_C155895 @default.
- NCIT_C155895 subClassOf NCIT_C1908 @default.
- NCIT_C155895 subClassOf NCIT_C1909 @default.
- NCIT_C155895 subClassOf NCIT_C200085 @default.
- NCIT_C155895 subClassOf NCIT_C2189 @default.
- NCIT_C155895 subClassOf NCIT_C274 @default.
- NCIT_C155895 subClassOf NCIT_C471 @default.
- NCIT_C155895 subClassOf NCIT_C61074 @default.