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- NCIT_C155909 IAO_0000115 "A preparation of autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-mesothelin M5 single chain variable fragment (scFv) fused to the costimulatory domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential immunomodulating and antineoplastic activities. After isolation, transduction, expansion in culture and reintroduction into the patient, the autologous anti-mesothelin CAR-CD3zeta-4-1BB-expressing T-cells specifically target and induce selective toxicity in mesothelin-expressing tumor cells. Mesothelin, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types." @default.
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- NCIT_C155909 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155909 NCIT_P107 "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells" @default.
- NCIT_C155909 NCIT_P108 "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells" @default.
- NCIT_C155909 NCIT_P208 "CL562768" @default.
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- NCIT_C155909 hasExactSynonym "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells" @default.
- NCIT_C155909 hasExactSynonym "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-lymphocytes" @default.
- NCIT_C155909 hasExactSynonym "Hu-CART-meso cells" @default.
- NCIT_C155909 hasExactSynonym "Mesothelin-specific CAR T-cells" @default.
- NCIT_C155909 inSubset NCIT_C116977 @default.
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- NCIT_C155909 inSubset NCIT_C128784 @default.
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- NCIT_C155909 type Class @default.
- NCIT_C155909 isDefinedBy ncit.owl @default.
- NCIT_C155909 label "Autologous Anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T-cells" @default.
- NCIT_C155909 subClassOf NCIT_C129820 @default.
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