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- NCIT_C155970 IAO_0000115 "A bispecific antibody possessing two antigen-recognition and binding sites, one for the CD3 complex, a group of T-cell surface glycoproteins that complex with the T-cell receptor (TCR), and one for the tumor-associated antigen (TAA) CD33, with potential immunostimulating and antineoplastic activities. Upon administration of anti-CD33/CD3 bispecific antibody GEM 333, this bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the CD33 antigen found on CD33-expressing tumor cells, thereby crosslinking tumor cells and CTLs. This activates and redirects CTLs to CD33-expressing tumor cells, which results in the CTL-mediated cell death of CD33-expressing tumor cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent hematopoietic stem and progenitor cells (HSPCs) and is overexpressed on a variety of cancer cell types, including acute myeloid leukemia (AML). It plays a key role in tumor initiation, proliferation and progression." @default.
- NCIT_C155970 NCIT_A32 NCIT_C1909 @default.
- NCIT_C155970 NCIT_NHC0 "C155970" @default.
- NCIT_C155970 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C155970 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155970 NCIT_P108 "Anti-CD33/CD3 Bispecific Antibody GEM 333" @default.
- NCIT_C155970 NCIT_P208 "CL562715" @default.
- NCIT_C155970 NCIT_P322 "GDC" @default.
- NCIT_C155970 NCIT_P329 "795023" @default.
- NCIT_C155970 NCIT_P330 "795023" @default.
- NCIT_C155970 NCIT_P375 "Anti-CD33/CD3 Bispecific Antibody GEM 333" @default.
- NCIT_C155970 NCIT_P399 "795023" @default.
- NCIT_C155970 NCIT_R124 NCIT_C17710 @default.
- NCIT_C155970 NCIT_R124 NCIT_C17828 @default.
- NCIT_C155970 NCIT_R124 NCIT_C18219 @default.
- NCIT_C155970 NCIT_R124 NCIT_C19986 @default.
- NCIT_C155970 NCIT_R124 NCIT_C40474 @default.
- NCIT_C155970 normalizedInformationContent "100" @default.
- NCIT_C155970 referenceCount "1" @default.
- NCIT_C155970 hasExactSynonym "Anti-CD33 Bispecific Antibody GEM 333" @default.
- NCIT_C155970 hasExactSynonym "Anti-CD33/Anti-CD3 Bispecific Antibody GEM 333" @default.
- NCIT_C155970 hasExactSynonym "Anti-CD33/CD3 Antibody GEM 333" @default.
- NCIT_C155970 hasExactSynonym "Anti-CD33/CD3 Bispecific Antibody GEM 333" @default.
- NCIT_C155970 hasExactSynonym "GEM 333" @default.
- NCIT_C155970 hasExactSynonym "GEM-333" @default.
- NCIT_C155970 hasExactSynonym "GEM333" @default.
- NCIT_C155970 inSubset NCIT_C128784 @default.
- NCIT_C155970 inSubset NCIT_C157711 @default.
- NCIT_C155970 inSubset NCIT_C157712 @default.
- NCIT_C155970 inSubset NCIT_C176424 @default.
- NCIT_C155970 inSubset NCIT_C177537 @default.
- NCIT_C155970 type Class @default.
- NCIT_C155970 isDefinedBy ncit.owl @default.
- NCIT_C155970 label "Anti-CD33/CD3 Bispecific Antibody GEM 333" @default.
- NCIT_C155970 subClassOf NCIT_C112883 @default.
- NCIT_C155970 subClassOf NCIT_C129821 @default.
- NCIT_C155970 subClassOf NCIT_C129822 @default.
- NCIT_C155970 subClassOf NCIT_C1454 @default.
- NCIT_C155970 subClassOf NCIT_C155970 @default.
- NCIT_C155970 subClassOf NCIT_C1908 @default.
- NCIT_C155970 subClassOf NCIT_C1909 @default.
- NCIT_C155970 subClassOf NCIT_C200367 @default.
- NCIT_C155970 subClassOf NCIT_C201282 @default.
- NCIT_C155970 subClassOf NCIT_C20401 @default.
- NCIT_C155970 subClassOf NCIT_C274 @default.
- NCIT_C155970 subClassOf NCIT_C28227 @default.
- NCIT_C155970 subClassOf NCIT_C307 @default.
- NCIT_C155970 subClassOf NCIT_C308 @default.