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- NCIT_C155981 IAO_0000115 "A mixture of single-stranded oligodeoxyribonucleotides derived from the intestinal mucosa of pigs, with anti-thrombotic, thrombolytic, and fibrinolytic activities. Upon administration, and although the exact mechanism of action has yet to be fully elucidated, defibrotide induces the release of prostaglandin I2 (PGI2), E2 (PGE2), and prostacyclin and reduces the expression of adhesion molecules on endothelial cells. This relaxes the smooth muscle of blood vessels and prevents platelets from adhering to each other and to the endothelium. This protects the endothelium lining bloods vessels. Defibrotide increases tissue plasminogen activator (t-PA) and decreases plasminogen activator inhibitor-1 activity. This increases the activity of plasmin, prevents blood clot formation and dissolves blood clots." @default.
- NCIT_C155981 NCIT_A5 NCIT_C1064 @default.
- NCIT_C155981 NCIT_NHC0 "C155981" @default.
- NCIT_C155981 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C155981 NCIT_P108 "Defibrotide" @default.
- NCIT_C155981 NCIT_P208 "CL562739" @default.
- NCIT_C155981 NCIT_P319 "568FY5I1YI" @default.
- NCIT_C155981 NCIT_P322 "FDA" @default.
- NCIT_C155981 normalizedInformationContent "100" @default.
- NCIT_C155981 referenceCount "1" @default.
- NCIT_C155981 hasExactSynonym "DEFIBROTIDE FREE ACID" @default.
- NCIT_C155981 hasExactSynonym "Defibrotide" @default.
- NCIT_C155981 inSubset NCIT_C173381 @default.
- NCIT_C155981 inSubset NCIT_C173383 @default.
- NCIT_C155981 inSubset NCIT_C63923 @default.
- NCIT_C155981 type Class @default.
- NCIT_C155981 isDefinedBy ncit.owl @default.
- NCIT_C155981 label "Defibrotide" @default.
- NCIT_C155981 subClassOf NCIT_C155981 @default.
- NCIT_C155981 subClassOf NCIT_C1908 @default.
- NCIT_C155981 subClassOf NCIT_C1909 @default.
- NCIT_C155981 subClassOf NCIT_C263 @default.
- NCIT_C155981 subClassOf NCIT_C78275 @default.