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- NCIT_C156002 IAO_0000115 "Soluble interleukin-6 receptor subunit alpha is encoded by the human IL6R gene. This protein, which is produced by metalloproteinase-mediated cleavage of the membrane-bound form, is involved in the modulation of interleukin-6-mediated signaling by CD4-positive T-lymphocytes." @default.
- NCIT_C156002 NCIT_NHC0 "C156002" @default.
- NCIT_C156002 NCIT_P100 "147880" @default.
- NCIT_C156002 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C156002 NCIT_P107 "Soluble Interleukin-6 Receptor Subunit Alpha" @default.
- NCIT_C156002 NCIT_P108 "Soluble Interleukin-6 Receptor Subunit Alpha" @default.
- NCIT_C156002 NCIT_P208 "CL562744" @default.
- NCIT_C156002 NCIT_P322 "CTRP" @default.
- NCIT_C156002 NCIT_P93 "P08887" @default.
- NCIT_C156002 NCIT_P98 "Interleukin-6 (IL6) can bind membrane-bound and soluble forms of the interleukin-6 receptor subunit alpha (IL6R) with similar affinities. IL6-soluble IL6R complexes can interact with either membrane-bound or soluble forms of interleukin-6 receptor subunit beta (IL6ST; gp130). Binding of IL6-sIL6R to membrane-bound gp130 promotes IL6-mediated signaling pathways (IL-6 trans-signaling), while binding to soluble gp130 inhibits IL-6 trans-signaling." @default.
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- NCIT_C156002 NCIT_R54 NCIT_C16612 @default.
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- NCIT_C156002 NCIT_R54 NCIT_C21295 @default.
- NCIT_C156002 NCIT_R54 NCIT_C38920 @default.
- NCIT_C156002 normalizedInformationContent "100" @default.
- NCIT_C156002 referenceCount "1" @default.
- NCIT_C156002 hasExactSynonym "Soluble CD126 Antigen" @default.
- NCIT_C156002 hasExactSynonym "Soluble CD126" @default.
- NCIT_C156002 hasExactSynonym "Soluble IL-6 Receptor Alpha" @default.
- NCIT_C156002 hasExactSynonym "Soluble IL-6 Receptor" @default.
- NCIT_C156002 hasExactSynonym "Soluble IL-6R Subunit Alpha" @default.
- NCIT_C156002 hasExactSynonym "Soluble IL-6R" @default.
- NCIT_C156002 hasExactSynonym "Soluble IL-6R-Alpha" @default.
- NCIT_C156002 hasExactSynonym "Soluble IL-6RA" @default.
- NCIT_C156002 hasExactSynonym "Soluble IL6R" @default.
- NCIT_C156002 hasExactSynonym "Soluble IL6RA" @default.
- NCIT_C156002 hasExactSynonym "Soluble Interleukin 6 Receptor Subunit Alpha" @default.
- NCIT_C156002 hasExactSynonym "Soluble Interleukin 6 Receptor" @default.
- NCIT_C156002 hasExactSynonym "Soluble Interleukin-6 Receptor Subunit Alpha" @default.
- NCIT_C156002 hasExactSynonym "Soluble Interleukin-6 Receptor" @default.
- NCIT_C156002 hasExactSynonym "Soluble gp80" @default.
- NCIT_C156002 hasExactSynonym "sIL-6R" @default.
- NCIT_C156002 hasExactSynonym "sIL-6RA" @default.
- NCIT_C156002 inSubset NCIT_C116977 @default.
- NCIT_C156002 inSubset NCIT_C142799 @default.
- NCIT_C156002 inSubset NCIT_C142800 @default.
- NCIT_C156002 type Class @default.
- NCIT_C156002 isDefinedBy ncit.owl @default.
- NCIT_C156002 label "Soluble Interleukin-6 Receptor Subunit Alpha" @default.
- NCIT_C156002 subClassOf NCIT_C156001 @default.
- NCIT_C156002 subClassOf NCIT_C156002 @default.
- NCIT_C156002 subClassOf NCIT_C17021 @default.
- NCIT_C156002 subClassOf NCIT_C17728 @default.
- NCIT_C156002 subClassOf NCIT_C20027 @default.
- NCIT_C156002 subClassOf NCIT_C26548 @default.
- NCIT_C156002 equivalentClass Ba5a867d3609cb86afb4f5abdff7f2dec @default.
- NCIT_C156002 equivalentClass Bed057ccc5c5e7b0f84393f10afff6ca9 @default.