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- NCIT_C156052 IAO_0000115 "A bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), and one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-BCMA/CD3 T-cell engaging antibody CC-93269, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival." @default.
- NCIT_C156052 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156052 NCIT_A7 NCIT_C97848 @default.
- NCIT_C156052 NCIT_NHC0 "C156052" @default.
- NCIT_C156052 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156052 NCIT_P107 "BCMA x CD3 T-cell Engaging Antibody CC-93269" @default.
- NCIT_C156052 NCIT_P108 "BCMA x CD3 T-cell Engaging Antibody CC-93269" @default.
- NCIT_C156052 NCIT_P208 "CL562897" @default.
- NCIT_C156052 NCIT_P322 "CTRP" @default.
- NCIT_C156052 NCIT_P322 "GDC" @default.
- NCIT_C156052 NCIT_P329 "795389" @default.
- NCIT_C156052 NCIT_P330 "795389" @default.
- NCIT_C156052 NCIT_P375 "BCMA x CD3 T-cell Engaging Antibody CC-93269" @default.
- NCIT_C156052 NCIT_P399 "795389" @default.
- NCIT_C156052 NCIT_R124 NCIT_C17710 @default.
- NCIT_C156052 NCIT_R124 NCIT_C17828 @default.
- NCIT_C156052 NCIT_R124 NCIT_C18219 @default.
- NCIT_C156052 NCIT_R124 NCIT_C19986 @default.
- NCIT_C156052 NCIT_R124 NCIT_C40474 @default.
- NCIT_C156052 normalizedInformationContent "100" @default.
- NCIT_C156052 referenceCount "1" @default.
- NCIT_C156052 hasExactSynonym "Anti-BCMA/CD3 Bispecific Antibody CC-93269" @default.
- NCIT_C156052 hasExactSynonym "BCMA x CD3 T Cell Engaging Antibody CC-93269" @default.
- NCIT_C156052 hasExactSynonym "BCMA x CD3 T-cell Engaging Antibody CC-93269" @default.
- NCIT_C156052 hasExactSynonym "BCMA/CD3 T-cell Bi-specific Antibody CC-93269" @default.
- NCIT_C156052 hasExactSynonym "BCMA/CD3-directed Bispecific T-cell Engager Antibody CC-93269" @default.
- NCIT_C156052 hasExactSynonym "BCMAxCD3 BiTE Antibody CC-93269" @default.
- NCIT_C156052 hasExactSynonym "BCMAxCD3 TCB CC-93269" @default.
- NCIT_C156052 hasExactSynonym "Bi-specific Antibody CC-93269" @default.
- NCIT_C156052 hasExactSynonym "CC 93269" @default.
- NCIT_C156052 hasExactSynonym "CC-93269" @default.
- NCIT_C156052 hasExactSynonym "EM901" @default.
- NCIT_C156052 inSubset NCIT_C116977 @default.
- NCIT_C156052 inSubset NCIT_C116978 @default.
- NCIT_C156052 inSubset NCIT_C128784 @default.
- NCIT_C156052 inSubset NCIT_C157711 @default.
- NCIT_C156052 inSubset NCIT_C157712 @default.
- NCIT_C156052 inSubset NCIT_C176424 @default.
- NCIT_C156052 inSubset NCIT_C177537 @default.
- NCIT_C156052 type Class @default.
- NCIT_C156052 isDefinedBy ncit.owl @default.
- NCIT_C156052 label "BCMA x CD3 T-cell Engaging Antibody CC-93269" @default.
- NCIT_C156052 subClassOf NCIT_C112883 @default.
- NCIT_C156052 subClassOf NCIT_C129821 @default.
- NCIT_C156052 subClassOf NCIT_C129822 @default.
- NCIT_C156052 subClassOf NCIT_C1454 @default.
- NCIT_C156052 subClassOf NCIT_C156052 @default.
- NCIT_C156052 subClassOf NCIT_C163758 @default.
- NCIT_C156052 subClassOf NCIT_C181111 @default.
- NCIT_C156052 subClassOf NCIT_C181113 @default.
- NCIT_C156052 subClassOf NCIT_C181114 @default.
- NCIT_C156052 subClassOf NCIT_C1908 @default.
- NCIT_C156052 subClassOf NCIT_C1909 @default.
- NCIT_C156052 subClassOf NCIT_C201282 @default.
- NCIT_C156052 subClassOf NCIT_C20401 @default.
- NCIT_C156052 subClassOf NCIT_C274 @default.
- NCIT_C156052 subClassOf NCIT_C28227 @default.
- NCIT_C156052 subClassOf NCIT_C307 @default.
- NCIT_C156052 subClassOf NCIT_C308 @default.