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- NCIT_C156061 IAO_0000115 "A type II humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting the ectoenzyme 5'-ecto-nucleotidase (cluster of differentiation 73; CD73; 5'-NT; ecto-5'-nucleotidase; NT5E), with potential immunomodulating and antineoplastic activities. Upon intravenous administration, mupadolimab targets and binds to CD73 on tumor cells, leading to internalization of CD73. This prevents CD73-mediated conversion of extracellular adenosine monophosphate (AMP) to adenosine, thereby preventing adenosine-mediated suppression of lymphocyte activity and increasing the activity of cytotoxic T-lymphocytes (CTLs). This also activates macrophages, and reduces the activity of both myeloid-derived suppressor cells (MDSCs) and regulatory T-lymphocytes. By abrogating the inhibitory effect on the immune system and enhancing the CTL-mediated immune response against cancer cells, tumor cell growth is decreased. CD73, a plasma membrane protein belonging to the 5'-nucleotidase (NTase) family, is upregulated on a number of cancer cell types and catalyzes the conversion of extracellular nucleotides, such as AMP, to membrane-permeable nucleosides, such as adenosine; it plays a key role in adenosine-mediated immunosuppression within the tumor microenvironment." @default.
- NCIT_C156061 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156061 NCIT_A7 NCIT_C114927 @default.
- NCIT_C156061 NCIT_NHC0 "C156061" @default.
- NCIT_C156061 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C156061 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C156061 NCIT_P107 "Mupadolimab" @default.
- NCIT_C156061 NCIT_P108 "Mupadolimab" @default.
- NCIT_C156061 NCIT_P208 "CL562920" @default.
- NCIT_C156061 NCIT_P210 "2451856-97-4" @default.
- NCIT_C156061 NCIT_P319 "23ET6940RM" @default.
- NCIT_C156061 NCIT_P322 "CTRP" @default.
- NCIT_C156061 NCIT_P322 "FDA" @default.
- NCIT_C156061 NCIT_P322 "GDC" @default.
- NCIT_C156061 NCIT_P329 "795397" @default.
- NCIT_C156061 NCIT_P330 "795397" @default.
- NCIT_C156061 NCIT_P375 "Anti-CD73 Monoclonal Antibody CPI-006" @default.
- NCIT_C156061 NCIT_P399 "795397" @default.
- NCIT_C156061 NCIT_R124 NCIT_C17710 @default.
- NCIT_C156061 NCIT_R124 NCIT_C17828 @default.
- NCIT_C156061 NCIT_R124 NCIT_C18219 @default.
- NCIT_C156061 NCIT_R124 NCIT_C19986 @default.
- NCIT_C156061 NCIT_R124 NCIT_C40474 @default.
- NCIT_C156061 normalizedInformationContent "100" @default.
- NCIT_C156061 referenceCount "1" @default.
- NCIT_C156061 hasExactSynonym "Anti-CD73 Monoclonal Antibody CPI-006" @default.
- NCIT_C156061 hasExactSynonym "CPI 006" @default.
- NCIT_C156061 hasExactSynonym "CPI-006" @default.
- NCIT_C156061 hasExactSynonym "CPI006" @default.
- NCIT_C156061 hasExactSynonym "CPX-006" @default.
- NCIT_C156061 hasExactSynonym "MUPADOLIMAB" @default.
- NCIT_C156061 hasExactSynonym "Mupadolimab" @default.
- NCIT_C156061 inSubset NCIT_C116977 @default.
- NCIT_C156061 inSubset NCIT_C116978 @default.
- NCIT_C156061 inSubset NCIT_C128784 @default.
- NCIT_C156061 inSubset NCIT_C157711 @default.
- NCIT_C156061 inSubset NCIT_C157712 @default.
- NCIT_C156061 inSubset NCIT_C173381 @default.
- NCIT_C156061 inSubset NCIT_C173383 @default.
- NCIT_C156061 inSubset NCIT_C176424 @default.
- NCIT_C156061 inSubset NCIT_C177537 @default.
- NCIT_C156061 inSubset NCIT_C63923 @default.
- NCIT_C156061 type Class @default.
- NCIT_C156061 isDefinedBy ncit.owl @default.
- NCIT_C156061 label "Mupadolimab" @default.
- NCIT_C156061 subClassOf NCIT_C129820 @default.
- NCIT_C156061 subClassOf NCIT_C129821 @default.
- NCIT_C156061 subClassOf NCIT_C129822 @default.
- NCIT_C156061 subClassOf NCIT_C156061 @default.
- NCIT_C156061 subClassOf NCIT_C176988 @default.
- NCIT_C156061 subClassOf NCIT_C1908 @default.
- NCIT_C156061 subClassOf NCIT_C1909 @default.
- NCIT_C156061 subClassOf NCIT_C201133 @default.
- NCIT_C156061 subClassOf NCIT_C20401 @default.
- NCIT_C156061 subClassOf NCIT_C274 @default.
- NCIT_C156061 subClassOf NCIT_C307 @default.
- NCIT_C156061 subClassOf NCIT_C308 @default.