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- NCIT_C156067 IAO_0000115 "A cancer cell vaccine consisting of autologous dendritic cells (DCs) loaded with mRNA encoding the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) as a fusion protein with the full-length lysosome-associated membrane protein (flLAMP), with potential immunostimulatory and antineoplastic activities. Upon vaccination, the autologous CMV-pp65-flLAMP mRNA loaded DC vaccine exposes the immune system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL) response against CMV pp65-expressing tumor cells. The incorporation of flLAMP may route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC class II antigen presentation, thereby promoting CD4-positive T-cell responses. The CMV pp65 protein is the primary component of the enveloped subviral particle of CMV and is expressed in certain tumor types." @default.
- NCIT_C156067 NCIT_A7 NCIT_C141213 @default.
- NCIT_C156067 NCIT_NHC0 "C156067" @default.
- NCIT_C156067 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C156067 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156067 NCIT_P107 "Autologous CMV-pp65-flLAMP mRNA Loaded Dendritic Cell Vaccine" @default.
- NCIT_C156067 NCIT_P108 "Autologous CMV-pp65-flLAMP mRNA Loaded Dendritic Cell Vaccine" @default.
- NCIT_C156067 NCIT_P208 "CL562918" @default.
- NCIT_C156067 NCIT_P322 "CTRP" @default.
- NCIT_C156067 NCIT_P329 "795394" @default.
- NCIT_C156067 NCIT_P330 "795394" @default.
- NCIT_C156067 NCIT_P399 "795394" @default.
- NCIT_C156067 normalizedInformationContent "100" @default.
- NCIT_C156067 referenceCount "1" @default.
- NCIT_C156067 hasExactSynonym "Autologous CMV pp65-LAMP mRNA-loaded DC Vaccine" @default.
- NCIT_C156067 hasExactSynonym "Autologous CMV-pp65-flLAMP mRNA Loaded Dendritic Cell Vaccine" @default.
- NCIT_C156067 hasExactSynonym "Autologous CMV-pp65-flLamp DCs" @default.
- NCIT_C156067 hasExactSynonym "Autologous flLAMP-pp65 mRNA-pulsed DC Vaccine" @default.
- NCIT_C156067 hasExactSynonym "Autologous flLAMP-pp65-DC Vaccine" @default.
- NCIT_C156067 hasExactSynonym "Autologous flLAMP-pp65-DCs" @default.
- NCIT_C156067 hasExactSynonym "Autologous pp65-flLAMP DC Vaccine" @default.
- NCIT_C156067 hasExactSynonym "Autologous pp65-flLAMP DCs" @default.
- NCIT_C156067 inSubset NCIT_C116977 @default.
- NCIT_C156067 inSubset NCIT_C116978 @default.
- NCIT_C156067 inSubset NCIT_C128784 @default.
- NCIT_C156067 inSubset NCIT_C176424 @default.
- NCIT_C156067 type Class @default.
- NCIT_C156067 isDefinedBy ncit.owl @default.
- NCIT_C156067 label "Autologous CMV-pp65-flLAMP mRNA Loaded Dendritic Cell Vaccine" @default.
- NCIT_C156067 subClassOf NCIT_C129820 @default.
- NCIT_C156067 subClassOf NCIT_C156067 @default.
- NCIT_C156067 subClassOf NCIT_C1663 @default.
- NCIT_C156067 subClassOf NCIT_C172787 @default.
- NCIT_C156067 subClassOf NCIT_C181141 @default.
- NCIT_C156067 subClassOf NCIT_C1908 @default.
- NCIT_C156067 subClassOf NCIT_C1909 @default.
- NCIT_C156067 subClassOf NCIT_C274 @default.
- NCIT_C156067 subClassOf NCIT_C28308 @default.
- NCIT_C156067 subClassOf NCIT_C28310 @default.
- NCIT_C156067 subClassOf NCIT_C307 @default.
- NCIT_C156067 subClassOf NCIT_C308 @default.
- NCIT_C156067 subClassOf NCIT_C923 @default.