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- NCIT_C156156 IAO_0000115 "A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a human epidermal growth factor receptor type 2 (HER2; EGFR2; ErbB2)-specific chimeric antigen receptor (CAR) coupled to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells are directed to and induce selective toxicity in HER2-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of these cells through an anti-EGFR antibody-induced antibody-dependent cellular cytotoxicity (ADCC) response. HER2, a receptor tyrosine kinase (RTK) overexpressed by a variety of tumor cell types, belongs to the EGFR superfamily and plays a key role in tumor cell proliferation." @default.
- NCIT_C156156 NCIT_NHC0 "C156156" @default.
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- NCIT_C156156 NCIT_P108 "Autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells" @default.
- NCIT_C156156 NCIT_P208 "CL562867" @default.
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- NCIT_C156156 hasExactSynonym "Autologous HER2 CAR/EGFRt-expressing CD4+ and CD8+ T-cells" @default.
- NCIT_C156156 hasExactSynonym "Autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells" @default.
- NCIT_C156156 inSubset NCIT_C128784 @default.
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- NCIT_C156156 type Class @default.
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- NCIT_C156156 label "Autologous HER2-specific/EGFRt-expressing CD4/CD8-positive CAR T-cells" @default.
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