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- NCIT_C156173 IAO_0000115 "A small molecule inhibitor of Bruton's tyrosine kinase (BTK; Bruton agammaglobulinemia tyrosine kinase) with potential antineoplastic activity. Upon administration, orelabrutinib binds to and inhibits the activity of BTK. This prevents both the activation of the B-cell antigen receptor (BCR) signaling pathway and BTK-mediated activation of downstream survival pathways, inhibiting the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed or mutated in B-cell malignancies; it plays an important role in the development, activation, signaling, proliferation and survival of B-lymphocytes." @default.
- NCIT_C156173 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156173 NCIT_NHC0 "C156173" @default.
- NCIT_C156173 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156173 NCIT_P107 "Orelabrutinib" @default.
- NCIT_C156173 NCIT_P108 "Orelabrutinib" @default.
- NCIT_C156173 NCIT_P208 "CL563002" @default.
- NCIT_C156173 NCIT_P210 "1655504-04-3" @default.
- NCIT_C156173 NCIT_P319 "WJA5UO9E10" @default.
- NCIT_C156173 NCIT_P322 "CTRP" @default.
- NCIT_C156173 NCIT_P322 "FDA" @default.
- NCIT_C156173 NCIT_P322 "GDC" @default.
- NCIT_C156173 NCIT_P329 "795368" @default.
- NCIT_C156173 NCIT_P330 "795368" @default.
- NCIT_C156173 NCIT_P375 "BTK Inhibitor ICP-022" @default.
- NCIT_C156173 NCIT_P375 "Orelabrutinib" @default.
- NCIT_C156173 NCIT_P399 "795368" @default.
- NCIT_C156173 normalizedInformationContent "100" @default.
- NCIT_C156173 referenceCount "1" @default.
- NCIT_C156173 hasExactSynonym "BTK Inhibitor ICP-022" @default.
- NCIT_C156173 hasExactSynonym "ICP 022" @default.
- NCIT_C156173 hasExactSynonym "ICP-022" @default.
- NCIT_C156173 hasExactSynonym "ICP022" @default.
- NCIT_C156173 hasExactSynonym "ORELABRUTINIB" @default.
- NCIT_C156173 hasExactSynonym "Orelabrutinib" @default.
- NCIT_C156173 inSubset NCIT_C116977 @default.
- NCIT_C156173 inSubset NCIT_C116978 @default.
- NCIT_C156173 inSubset NCIT_C128784 @default.
- NCIT_C156173 inSubset NCIT_C157711 @default.
- NCIT_C156173 inSubset NCIT_C157712 @default.
- NCIT_C156173 inSubset NCIT_C176424 @default.
- NCIT_C156173 inSubset NCIT_C177537 @default.
- NCIT_C156173 inSubset NCIT_C63923 @default.
- NCIT_C156173 type Class @default.
- NCIT_C156173 isDefinedBy ncit.owl @default.
- NCIT_C156173 label "Orelabrutinib" @default.
- NCIT_C156173 subClassOf NCIT_C124801 @default.
- NCIT_C156173 subClassOf NCIT_C129824 @default.
- NCIT_C156173 subClassOf NCIT_C129825 @default.
- NCIT_C156173 subClassOf NCIT_C1404 @default.
- NCIT_C156173 subClassOf NCIT_C156173 @default.
- NCIT_C156173 subClassOf NCIT_C163758 @default.
- NCIT_C156173 subClassOf NCIT_C163774 @default.
- NCIT_C156173 subClassOf NCIT_C1908 @default.
- NCIT_C156173 subClassOf NCIT_C1909 @default.
- NCIT_C156173 subClassOf NCIT_C1967 @default.
- NCIT_C156173 subClassOf NCIT_C2189 @default.
- NCIT_C156173 subClassOf NCIT_C274 @default.
- NCIT_C156173 subClassOf NCIT_C471 @default.