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- NCIT_C156175 IAO_0000115 "An orally available capsule containing alkylglycerols and Rosmarinus officinalis extracts standardized to diterpenes, including carnosic acid and carnosol, with potential antineoplastic and anti-inflammatory activities. Upon administration, carnosic acid and carnosol may induce apoptosis by decreasing apoptosis regulator B-cell lymphoma 2 (Bcl-2) expression, decrease tumor cell growth through inhibition of mammalian target of rapamycin (mTOR) phosphorylation, and inhibit metastatic activity by preventing the adhesion of tumor cells to type I collagen and fibronectin. Additionally, these diterpenes may decrease inflammation by downregulating cyclooxygenase (COX) type 2 (COX-2) protein synthesis. Alkylglycerols (alkyl-Gro) are bioactive ether lipids that may, through a not yet fully elucidated mechanism, inhibit tumor cell growth and metastases." @default.
- NCIT_C156175 NCIT_NHC0 "C156175" @default.
- NCIT_C156175 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156175 NCIT_P108 "Alkylglycerol/Rosemary Capsules" @default.
- NCIT_C156175 NCIT_P208 "CL563027" @default.
- NCIT_C156175 NCIT_P329 "795374" @default.
- NCIT_C156175 NCIT_P330 "795374" @default.
- NCIT_C156175 NCIT_P399 "795374" @default.
- NCIT_C156175 normalizedInformationContent "100" @default.
- NCIT_C156175 referenceCount "1" @default.
- NCIT_C156175 hasExactSynonym "Alkylglycerol and Rosemary Capsules" @default.
- NCIT_C156175 hasExactSynonym "Alkylglycerol/Rosemary Capsules" @default.
- NCIT_C156175 hasExactSynonym "Rosemary/Alkylglycerol Dietary Supplement" @default.
- NCIT_C156175 inSubset NCIT_C128784 @default.
- NCIT_C156175 inSubset NCIT_C176424 @default.
- NCIT_C156175 type Class @default.
- NCIT_C156175 isDefinedBy ncit.owl @default.
- NCIT_C156175 label "Alkylglycerol/Rosemary Capsules" @default.
- NCIT_C156175 subClassOf NCIT_C1505 @default.
- NCIT_C156175 subClassOf NCIT_C156175 @default.
- NCIT_C156175 subClassOf NCIT_C1907 @default.
- NCIT_C156175 subClassOf NCIT_C1908 @default.
- NCIT_C156175 subClassOf NCIT_C1909 @default.
- NCIT_C156175 subClassOf NCIT_C1931 @default.
- NCIT_C156175 subClassOf NCIT_C274 @default.