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- NCIT_C156177 IAO_0000115 "A recombinant, human Fc-inert monoclonal antibody targeting lymphocyte-activation gene 3 protein (LAG-3; LAG3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration, monoclonal antibody Sym022 binds to human LAG-3 and blocks the interaction between LAG-3 and major histocompatibility complex class II (MHCII) molecules on the surface of antigen-presenting cells (APCs) and tumor cells. This prevents the negative regulation of T-cell activity that occurs via LAG-3-MHCII binding and enhances a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Additionally, Sym022 decreases LAG-3 surface levels through internalization and shredding. LAG-3 plays a key role in the activation of T-cells and natural killer (NK) cells." @default.
- NCIT_C156177 NCIT_A7 NCIT_C104623 @default.
- NCIT_C156177 NCIT_NHC0 "C156177" @default.
- NCIT_C156177 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C156177 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156177 NCIT_P107 "Anti-LAG-3 Monoclonal Antibody Sym022" @default.
- NCIT_C156177 NCIT_P108 "Anti-LAG-3 Monoclonal Antibody Sym022" @default.
- NCIT_C156177 NCIT_P208 "CL563029" @default.
- NCIT_C156177 NCIT_P210 "2250088-52-7" @default.
- NCIT_C156177 NCIT_P319 "7TQ52FVC2L" @default.
- NCIT_C156177 NCIT_P322 "CTRP" @default.
- NCIT_C156177 NCIT_P322 "FDA" @default.
- NCIT_C156177 NCIT_P329 "795379" @default.
- NCIT_C156177 NCIT_P330 "795379" @default.
- NCIT_C156177 NCIT_P399 "795379" @default.
- NCIT_C156177 NCIT_R124 NCIT_C17710 @default.
- NCIT_C156177 NCIT_R124 NCIT_C17828 @default.
- NCIT_C156177 NCIT_R124 NCIT_C18219 @default.
- NCIT_C156177 NCIT_R124 NCIT_C19986 @default.
- NCIT_C156177 NCIT_R124 NCIT_C40474 @default.
- NCIT_C156177 normalizedInformationContent "100" @default.
- NCIT_C156177 referenceCount "1" @default.
- NCIT_C156177 hasExactSynonym "Anti-LAG-3 Monoclonal Antibody Sym022" @default.
- NCIT_C156177 hasExactSynonym "SYM-022" @default.
- NCIT_C156177 hasExactSynonym "Sym 022" @default.
- NCIT_C156177 hasExactSynonym "Sym-022" @default.
- NCIT_C156177 hasExactSynonym "Sym022" @default.
- NCIT_C156177 inSubset NCIT_C116977 @default.
- NCIT_C156177 inSubset NCIT_C116978 @default.
- NCIT_C156177 inSubset NCIT_C128784 @default.
- NCIT_C156177 inSubset NCIT_C176424 @default.
- NCIT_C156177 inSubset NCIT_C63923 @default.
- NCIT_C156177 type Class @default.
- NCIT_C156177 isDefinedBy ncit.owl @default.
- NCIT_C156177 label "Anti-LAG-3 Monoclonal Antibody Sym022" @default.
- NCIT_C156177 subClassOf NCIT_C129821 @default.
- NCIT_C156177 subClassOf NCIT_C129822 @default.
- NCIT_C156177 subClassOf NCIT_C134305 @default.
- NCIT_C156177 subClassOf NCIT_C141144 @default.
- NCIT_C156177 subClassOf NCIT_C143250 @default.
- NCIT_C156177 subClassOf NCIT_C156177 @default.
- NCIT_C156177 subClassOf NCIT_C163758 @default.
- NCIT_C156177 subClassOf NCIT_C1908 @default.
- NCIT_C156177 subClassOf NCIT_C1909 @default.
- NCIT_C156177 subClassOf NCIT_C200483 @default.
- NCIT_C156177 subClassOf NCIT_C20401 @default.
- NCIT_C156177 subClassOf NCIT_C274 @default.
- NCIT_C156177 subClassOf NCIT_C307 @default.
- NCIT_C156177 subClassOf NCIT_C308 @default.