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- NCIT_C156249 IAO_0000115 "An orally bioavailable and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, lisaftoclax targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival." @default.
- NCIT_C156249 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156249 NCIT_A7 NCIT_C153109 @default.
- NCIT_C156249 NCIT_NHC0 "C156249" @default.
- NCIT_C156249 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156249 NCIT_P107 "Lisaftoclax" @default.
- NCIT_C156249 NCIT_P108 "Lisaftoclax" @default.
- NCIT_C156249 NCIT_P208 "CL562961" @default.
- NCIT_C156249 NCIT_P210 "2180923-05-9" @default.
- NCIT_C156249 NCIT_P319 "OSL3FEZ1IF" @default.
- NCIT_C156249 NCIT_P322 "CTRP" @default.
- NCIT_C156249 NCIT_P322 "FDA" @default.
- NCIT_C156249 NCIT_P322 "GDC" @default.
- NCIT_C156249 NCIT_P329 "795558" @default.
- NCIT_C156249 NCIT_P330 "795558" @default.
- NCIT_C156249 NCIT_P375 "Bcl-2 Inhibitor APG 2575" @default.
- NCIT_C156249 NCIT_P399 "795558" @default.
- NCIT_C156249 normalizedInformationContent "100" @default.
- NCIT_C156249 referenceCount "1" @default.
- NCIT_C156249 hasExactSynonym "APG 2575" @default.
- NCIT_C156249 hasExactSynonym "APG-2575" @default.
- NCIT_C156249 hasExactSynonym "APG2575" @default.
- NCIT_C156249 hasExactSynonym "Bcl-2 Inhibitor APG 2575" @default.
- NCIT_C156249 hasExactSynonym "LISAFTOCLAX" @default.
- NCIT_C156249 hasExactSynonym "Lisaftoclax" @default.
- NCIT_C156249 inSubset NCIT_C116977 @default.
- NCIT_C156249 inSubset NCIT_C116978 @default.
- NCIT_C156249 inSubset NCIT_C128784 @default.
- NCIT_C156249 inSubset NCIT_C157711 @default.
- NCIT_C156249 inSubset NCIT_C157712 @default.
- NCIT_C156249 inSubset NCIT_C176424 @default.
- NCIT_C156249 inSubset NCIT_C177537 @default.
- NCIT_C156249 inSubset NCIT_C63923 @default.
- NCIT_C156249 type Class @default.
- NCIT_C156249 isDefinedBy ncit.owl @default.
- NCIT_C156249 label "Lisaftoclax" @default.
- NCIT_C156249 subClassOf NCIT_C129839 @default.
- NCIT_C156249 subClassOf NCIT_C156249 @default.
- NCIT_C156249 subClassOf NCIT_C159200 @default.
- NCIT_C156249 subClassOf NCIT_C163758 @default.
- NCIT_C156249 subClassOf NCIT_C1908 @default.
- NCIT_C156249 subClassOf NCIT_C1909 @default.
- NCIT_C156249 subClassOf NCIT_C192025 @default.
- NCIT_C156249 subClassOf NCIT_C274 @default.