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- NCIT_C156251 IAO_0000115 "Autologous human T-lymphocytes transduced with a recombinant lentiviral vector encoding a chimeric antigen receptor (CAR) consisting of an anti-CD22 human single chain variable fragment (scFv) and linked to the co-stimulatory domain 4-1BB (CD137) coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta), with potential immunostimulating and antineoplastic activities. Upon reintroduction into the patient, the autologous anti-CD22 CAR-4-1BB-TCRz -transduced T-lymphocytes CART22-65s express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces, resulting in lysis of CD22-expressing tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells." @default.
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- NCIT_C156251 NCIT_P107 "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s" @default.
- NCIT_C156251 NCIT_P108 "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s" @default.
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- NCIT_C156251 hasExactSynonym "Autologous Anti-CD22 CAR T-Cells CART22-65s" @default.
- NCIT_C156251 hasExactSynonym "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s" @default.
- NCIT_C156251 hasExactSynonym "Autologous Anti-CD22 scFv CAR 4-1BB-TCRz-expressing T-lymphocytes CART22-65s" @default.
- NCIT_C156251 hasExactSynonym "Autologous CART22-65s Cells" @default.
- NCIT_C156251 hasExactSynonym "Autologous CART22-65s T-cells" @default.
- NCIT_C156251 hasExactSynonym "Autologous CART22-65s-expressing T-cells" @default.
- NCIT_C156251 hasExactSynonym "CART22-65s" @default.
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- NCIT_C156251 type Class @default.
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- NCIT_C156251 label "Autologous Anti-CD22 CAR-4-1BB-TCRz-transduced T-lymphocytes CART22-65s" @default.
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