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- NCIT_C156382 IAO_0000115 "A preparation of autologous CD4+ and CD62L-expressing CD8+ T-cells transduced with a third generation lentiviral vector (LV) to express the high affinity T-cell receptor (TCR) A2 -MCC1, specific for the human leukocyte antigen (HLA)-A02-restricted Merkel cell polyomavirus (MCPyV; MCV) viral oncoprotein, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, the autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD8+ and CD4+ T-cells FH-MCVA2TCR selectively bind to the KLLEIAPNC epitope (KLL epitope) within the MCPyV viral oncoprotein. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the MCPyV viral oncoprotein. Additionally, tumor-specific HLA-A02-restricted CD4+ cells promote class I-restricted CD8+ proliferation, survival and effector functions by producing interleukin (IL)-2 and facilitating the activation of dendritic cells (DCs). MCPyV viral oncoprotein is highly expressed in Merkel cell carcinoma (MCC) caused by MCPyV." @default.
- NCIT_C156382 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156382 NCIT_A7 NCIT_C73535 @default.
- NCIT_C156382 NCIT_NHC0 "C156382" @default.
- NCIT_C156382 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156382 NCIT_P107 "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR" @default.
- NCIT_C156382 NCIT_P108 "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR" @default.
- NCIT_C156382 NCIT_P208 "CL563078" @default.
- NCIT_C156382 NCIT_P322 "CTRP" @default.
- NCIT_C156382 NCIT_P322 "GDC" @default.
- NCIT_C156382 NCIT_P329 "795693" @default.
- NCIT_C156382 NCIT_P330 "795693" @default.
- NCIT_C156382 NCIT_P375 "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR" @default.
- NCIT_C156382 NCIT_P399 "795693" @default.
- NCIT_C156382 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C156382 NCIT_R72 NCIT_C39568 @default.
- NCIT_C156382 normalizedInformationContent "100" @default.
- NCIT_C156382 referenceCount "1" @default.
- NCIT_C156382 hasExactSynonym "Autologous CD8+ and CD4+ T-cells transduced with TCR A2-MCC1" @default.
- NCIT_C156382 hasExactSynonym "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR" @default.
- NCIT_C156382 hasExactSynonym "FH-MCVA2TCR Autologous CD8+ and CD4+ T-cells Transduced with TCR A2-MCC1" @default.
- NCIT_C156382 hasExactSynonym "FH-MCVA2TCR" @default.
- NCIT_C156382 inSubset NCIT_C116977 @default.
- NCIT_C156382 inSubset NCIT_C116978 @default.
- NCIT_C156382 inSubset NCIT_C128784 @default.
- NCIT_C156382 inSubset NCIT_C157711 @default.
- NCIT_C156382 inSubset NCIT_C157712 @default.
- NCIT_C156382 inSubset NCIT_C176424 @default.
- NCIT_C156382 inSubset NCIT_C177537 @default.
- NCIT_C156382 type Class @default.
- NCIT_C156382 isDefinedBy ncit.owl @default.
- NCIT_C156382 label "Autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T-cells FH-MCVA2TCR" @default.
- NCIT_C156382 subClassOf NCIT_C129820 @default.
- NCIT_C156382 subClassOf NCIT_C129821 @default.
- NCIT_C156382 subClassOf NCIT_C129826 @default.
- NCIT_C156382 subClassOf NCIT_C138180 @default.
- NCIT_C156382 subClassOf NCIT_C142078 @default.
- NCIT_C156382 subClassOf NCIT_C154231 @default.
- NCIT_C156382 subClassOf NCIT_C156382 @default.
- NCIT_C156382 subClassOf NCIT_C1908 @default.
- NCIT_C156382 subClassOf NCIT_C1909 @default.
- NCIT_C156382 subClassOf NCIT_C1962 @default.
- NCIT_C156382 subClassOf NCIT_C274 @default.
- NCIT_C156382 subClassOf NCIT_C28681 @default.
- NCIT_C156382 subClassOf NCIT_C307 @default.
- NCIT_C156382 subClassOf NCIT_C308 @default.