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- NCIT_C156396 IAO_0000115 "A combination preparation containing ceftolozane, a semi-synthetic, broad-spectrum, fifth-generation cephalosporin and tazobactam, a beta-lactamase inhibitor, with activity against Gram-negative and Gram-positive bacteria. Upon intravenous administration, ceftolozane binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. This interferes with the final transpeptidation step required to form peptidoglycan chain cross-links, which are a key component of and provide strength and rigidity to the bacterial cell wall. This inhibits bacterial cell wall synthesis and reduces cell wall stability, which weakens the bacterial cell wall and causes bacterial cell lysis. Tazobactam irreversibly inhibits certain penicillinases and cephalosporinases and covalently binds to some chromosomal and plasmid-mediated bacterial beta-lactamases, thereby protecting ceftolozane from degradation and improving ceftolozane's activity." @default.
- NCIT_C156396 NCIT_NHC0 "C156396" @default.
- NCIT_C156396 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156396 NCIT_P108 "Ceftolozane-Tazobactam" @default.
- NCIT_C156396 NCIT_P207 "C3656593" @default.
- NCIT_C156396 NCIT_P329 "795424" @default.
- NCIT_C156396 NCIT_P330 "795424" @default.
- NCIT_C156396 NCIT_P399 "795424" @default.
- NCIT_C156396 normalizedInformationContent "100" @default.
- NCIT_C156396 referenceCount "1" @default.
- NCIT_C156396 hasExactSynonym "CXA 201" @default.
- NCIT_C156396 hasExactSynonym "CXA-201" @default.
- NCIT_C156396 hasExactSynonym "CXA201" @default.
- NCIT_C156396 hasExactSynonym "Ceftolozane-Tazobactam" @default.
- NCIT_C156396 hasExactSynonym "Ceftolozane/Tazobactam" @default.
- NCIT_C156396 hasExactSynonym "Zerbaxa" @default.
- NCIT_C156396 inSubset NCIT_C176424 @default.
- NCIT_C156396 type Class @default.
- NCIT_C156396 isDefinedBy ncit.owl @default.
- NCIT_C156396 label "Ceftolozane-Tazobactam" @default.
- NCIT_C156396 subClassOf NCIT_C156396 @default.
- NCIT_C156396 subClassOf NCIT_C1908 @default.
- NCIT_C156396 subClassOf NCIT_C1909 @default.
- NCIT_C156396 subClassOf NCIT_C254 @default.
- NCIT_C156396 subClassOf NCIT_C258 @default.
- NCIT_C156396 subClassOf NCIT_C260 @default.
- NCIT_C156396 subClassOf NCIT_C357 @default.