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- NCIT_C156415 IAO_0000115 "An orally available inhibitor of MDM2 (murine double minute 2), with potential antineoplastic activity. Upon oral administration, MDM2 inhibitor KRT-232 binds to the MDM2 protein and prevents its binding to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the transcriptional activity of p53 is restored. This leads to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it plays a key role in cancer cell proliferation and survival." @default.
- NCIT_C156415 NCIT_NHC0 "C156415" @default.
- NCIT_C156415 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156415 NCIT_P108 "MDM2 Inhibitor KRT-232" @default.
- NCIT_C156415 NCIT_P200 "C162996" @default.
- NCIT_C156415 NCIT_P310 "Retired_Concept" @default.
- NCIT_C156415 NCIT_P98 "Thu Mar 05 15:41:54 EST 2020 - See 'MDM2 Inhibitor AMG-232(C116624)'" @default.
- NCIT_C156415 normalizedInformationContent "100" @default.
- NCIT_C156415 referenceCount "1" @default.
- NCIT_C156415 hasExactSynonym "MDM2 Inhibitor KRT-232" @default.
- NCIT_C156415 type Class @default.
- NCIT_C156415 isDefinedBy ncit.owl @default.
- NCIT_C156415 label "MDM2 Inhibitor KRT-232" @default.
- NCIT_C156415 subClassOf NCIT_C156415 @default.
- NCIT_C156415 subClassOf NCIT_C176957 @default.
- NCIT_C156415 subClassOf NCIT_C28428 @default.
- NCIT_C156415 deprecated "true" @default.