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- NCIT_C156490 IAO_0000115 "A mouse/human cross-reactive immunoglobulin G2 (IgG2) monoclonal antibody against the immune checkpoint immunoglobulin-like domain containing receptor 2 (ILDR2; Chromosome 1 Open Reading Frame 32; C1orf32), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, bapotulimab targets, binds to and inhibits ILDR2, thereby blocking the immunosuppressive activity of ILDR2. This prevents ILDR2-mediated inhibition of T-cell activities and induces a cytotoxic T-lymphocyte (CTL) response against tumor cells. ILDR2, a type I transmembrane protein belonging to the B7 family of immunomodulatory receptors, negatively regulates T-cell responses." @default.
- NCIT_C156490 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156490 NCIT_A7 NCIT_C156669 @default.
- NCIT_C156490 NCIT_NHC0 "C156490" @default.
- NCIT_C156490 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C156490 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156490 NCIT_P107 "Bapotulimab" @default.
- NCIT_C156490 NCIT_P108 "Bapotulimab" @default.
- NCIT_C156490 NCIT_P208 "CL935671" @default.
- NCIT_C156490 NCIT_P210 "2359413-58-2" @default.
- NCIT_C156490 NCIT_P319 "I92BM16NTD" @default.
- NCIT_C156490 NCIT_P322 "CTRP" @default.
- NCIT_C156490 NCIT_P322 "FDA" @default.
- NCIT_C156490 NCIT_P322 "GDC" @default.
- NCIT_C156490 NCIT_P329 "795831" @default.
- NCIT_C156490 NCIT_P330 "795831" @default.
- NCIT_C156490 NCIT_P375 "Anti-ILDR2 Monoclonal Antibody BAY 1905254" @default.
- NCIT_C156490 NCIT_P399 "795831" @default.
- NCIT_C156490 NCIT_R124 NCIT_C17710 @default.
- NCIT_C156490 NCIT_R124 NCIT_C17828 @default.
- NCIT_C156490 NCIT_R124 NCIT_C18219 @default.
- NCIT_C156490 NCIT_R124 NCIT_C19986 @default.
- NCIT_C156490 NCIT_R124 NCIT_C40474 @default.
- NCIT_C156490 normalizedInformationContent "100" @default.
- NCIT_C156490 referenceCount "1" @default.
- NCIT_C156490 hasExactSynonym "Anti-ILDR2 Inhibitor BAY1905254" @default.
- NCIT_C156490 hasExactSynonym "Anti-ILDR2 Monoclonal Antibody BAY 1905254" @default.
- NCIT_C156490 hasExactSynonym "Anti-immunoglobulin-like Domain Containing Receptor 2 MoAb BAY1905254" @default.
- NCIT_C156490 hasExactSynonym "BAPOTULIMAB" @default.
- NCIT_C156490 hasExactSynonym "BAY 1905254" @default.
- NCIT_C156490 hasExactSynonym "BAY-1905254" @default.
- NCIT_C156490 hasExactSynonym "BAY1905254" @default.
- NCIT_C156490 hasExactSynonym "Bapotulimab" @default.
- NCIT_C156490 hasExactSynonym "ILDR2 Function-blocking Antibody BAY1905254" @default.
- NCIT_C156490 hasExactSynonym "Immune Checkpoint Inhibitor BAY1905254" @default.
- NCIT_C156490 inSubset NCIT_C116977 @default.
- NCIT_C156490 inSubset NCIT_C116978 @default.
- NCIT_C156490 inSubset NCIT_C128784 @default.
- NCIT_C156490 inSubset NCIT_C157711 @default.
- NCIT_C156490 inSubset NCIT_C157712 @default.
- NCIT_C156490 inSubset NCIT_C176424 @default.
- NCIT_C156490 inSubset NCIT_C177537 @default.
- NCIT_C156490 inSubset NCIT_C63923 @default.
- NCIT_C156490 type Class @default.
- NCIT_C156490 isDefinedBy ncit.owl @default.
- NCIT_C156490 label "Bapotulimab" @default.
- NCIT_C156490 subClassOf NCIT_C129821 @default.
- NCIT_C156490 subClassOf NCIT_C129822 @default.
- NCIT_C156490 subClassOf NCIT_C156490 @default.
- NCIT_C156490 subClassOf NCIT_C1908 @default.
- NCIT_C156490 subClassOf NCIT_C1909 @default.
- NCIT_C156490 subClassOf NCIT_C20401 @default.
- NCIT_C156490 subClassOf NCIT_C274 @default.
- NCIT_C156490 subClassOf NCIT_C307 @default.
- NCIT_C156490 subClassOf NCIT_C308 @default.