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- NCIT_C1566 IAO_0000115 "A liposome-encapsulated formulation of the polyene antifungal antibiotic amphotericin B produced by the bacterium Streptomyces nodosus with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, and alters cell membrane integrity, resulting in leakage of intracellular components and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Compared to amphotericin B alone, liposomal delivery of amphotericin B allows for a greater drug concentration in target tissues while decreasing systemic side effects." @default.
- NCIT_C1566 NCIT_NHC0 "C1566" @default.
- NCIT_C1566 NCIT_P106 "Antibiotic" @default.
- NCIT_C1566 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1566 NCIT_P107 "Liposomal Amphotericin B" @default.
- NCIT_C1566 NCIT_P108 "Liposomal Amphotericin B" @default.
- NCIT_C1566 NCIT_P207 "C1145701" @default.
- NCIT_C1566 NCIT_P322 "CTRP" @default.
- NCIT_C1566 NCIT_P329 "43048" @default.
- NCIT_C1566 NCIT_P330 "43048" @default.
- NCIT_C1566 NCIT_P366 "Amphotericin_B-Lipid_Complex" @default.
- NCIT_C1566 NCIT_P399 "43048" @default.
- NCIT_C1566 normalizedInformationContent "100" @default.
- NCIT_C1566 referenceCount "1" @default.
- NCIT_C1566 hasExactSynonym "Abelcet" @default.
- NCIT_C1566 hasExactSynonym "AmBisome" @default.
- NCIT_C1566 hasExactSynonym "Amphotericin B Liposomal" @default.
- NCIT_C1566 hasExactSynonym "Amphotericin B-Lipid Complex" @default.
- NCIT_C1566 hasExactSynonym "DKF-5122" @default.
- NCIT_C1566 hasExactSynonym "L-AMB" @default.
- NCIT_C1566 hasExactSynonym "Lipid Complex, Amphotericin B" @default.
- NCIT_C1566 hasExactSynonym "Liposomal Amphotericin B" @default.
- NCIT_C1566 inSubset NCIT_C116977 @default.
- NCIT_C1566 inSubset NCIT_C116978 @default.
- NCIT_C1566 inSubset NCIT_C176424 @default.
- NCIT_C1566 type Class @default.
- NCIT_C1566 isDefinedBy ncit.owl @default.
- NCIT_C1566 label "Liposomal Amphotericin B" @default.
- NCIT_C1566 subClassOf NCIT_C1566 @default.
- NCIT_C1566 subClassOf NCIT_C1908 @default.
- NCIT_C1566 subClassOf NCIT_C1909 @default.
- NCIT_C1566 subClassOf NCIT_C254 @default.
- NCIT_C1566 subClassOf NCIT_C514 @default.