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- NCIT_C156665 IAO_0000115 "A formulation composed of dissolvable small, adhesive-like patches composed of a biocompatible material which is coated with the anthracycline antibiotic doxorubicin, with potential antineoplastic and immunomodulating activities. Upon cutaneous administration of the microneedle-array-doxorubicin, the microneedles degrade once inserted into the skin and doxorubicin is released from the dissolvable microneedle array delivery device directly into the tumor microenvironment (TME). Doxorubicin is taken up by tumor cells and intercalates into DNA and interferes with topoisomerase II activity. This inhibits DNA replication and RNA synthesis, leading to tumor cell growth inhibition and apoptosis. This agent also interacts with cell membrane lipids causing lipid peroxidation. In addition, doxorubicin induces innate, adaptive, and tumor-specific effector and memory immune responses, thereby further killing the tumor cells. Delivery of doxorubicin using the microneedle array delivery system allows direct and specific administration of doxorubicin to the TME which may improve drug concentration into tumor cells and may reduce systemic toxicity, compared to the administration of systemic doxorubicin alone." @default.
- NCIT_C156665 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156665 NCIT_A7 NCIT_C18434 @default.
- NCIT_C156665 NCIT_NHC0 "C156665" @default.
- NCIT_C156665 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156665 NCIT_P107 "Micro Needle Array-Doxorubicin" @default.
- NCIT_C156665 NCIT_P108 "Micro Needle Array-Doxorubicin" @default.
- NCIT_C156665 NCIT_P208 "CL935685" @default.
- NCIT_C156665 NCIT_P322 "CTRP" @default.
- NCIT_C156665 NCIT_P322 "GDC" @default.
- NCIT_C156665 NCIT_P329 "795832" @default.
- NCIT_C156665 NCIT_P330 "795832" @default.
- NCIT_C156665 NCIT_P375 "Micro Needle Array-Doxorubicin" @default.
- NCIT_C156665 NCIT_P399 "795832" @default.
- NCIT_C156665 normalizedInformationContent "100" @default.
- NCIT_C156665 referenceCount "1" @default.
- NCIT_C156665 hasExactSynonym "D-MNA" @default.
- NCIT_C156665 hasExactSynonym "Dissolvable Microneedles-containing Doxorubicin" @default.
- NCIT_C156665 hasExactSynonym "Doxorubicin-coated Patches" @default.
- NCIT_C156665 hasExactSynonym "Doxorubicin-loaded Patches" @default.
- NCIT_C156665 hasExactSynonym "MNA-D Patches" @default.
- NCIT_C156665 hasExactSynonym "MNA-D" @default.
- NCIT_C156665 hasExactSynonym "MNA-Doxorubicin" @default.
- NCIT_C156665 hasExactSynonym "Micro Needle Array-Doxorubicin" @default.
- NCIT_C156665 hasExactSynonym "Micro-needle Array Doxorubicin" @default.
- NCIT_C156665 hasExactSynonym "Microneedle Applicator-Doxorubicin" @default.
- NCIT_C156665 hasExactSynonym "Microneedle Array Doxorubicin" @default.
- NCIT_C156665 inSubset NCIT_C116977 @default.
- NCIT_C156665 inSubset NCIT_C116978 @default.
- NCIT_C156665 inSubset NCIT_C128784 @default.
- NCIT_C156665 inSubset NCIT_C157711 @default.
- NCIT_C156665 inSubset NCIT_C157712 @default.
- NCIT_C156665 inSubset NCIT_C176424 @default.
- NCIT_C156665 inSubset NCIT_C177537 @default.
- NCIT_C156665 type Class @default.
- NCIT_C156665 isDefinedBy ncit.owl @default.
- NCIT_C156665 label "Micro Needle Array-Doxorubicin" @default.
- NCIT_C156665 subClassOf NCIT_C129824 @default.
- NCIT_C156665 subClassOf NCIT_C129825 @default.
- NCIT_C156665 subClassOf NCIT_C156665 @default.
- NCIT_C156665 subClassOf NCIT_C1594 @default.
- NCIT_C156665 subClassOf NCIT_C1748 @default.
- NCIT_C156665 subClassOf NCIT_C186664 @default.
- NCIT_C156665 subClassOf NCIT_C1908 @default.
- NCIT_C156665 subClassOf NCIT_C1909 @default.
- NCIT_C156665 subClassOf NCIT_C1968 @default.
- NCIT_C156665 subClassOf NCIT_C2115 @default.
- NCIT_C156665 subClassOf NCIT_C2161 @default.
- NCIT_C156665 subClassOf NCIT_C2189 @default.
- NCIT_C156665 subClassOf NCIT_C259 @default.
- NCIT_C156665 subClassOf NCIT_C274 @default.
- NCIT_C156665 subClassOf NCIT_C2842 @default.
- NCIT_C156665 subClassOf NCIT_C471 @default.
- NCIT_C156665 subClassOf NCIT_C67502 @default.