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- NCIT_C156680 IAO_0000115 "A phosphoramidate-based prodrug of the monophosphate (MP) form of 5-fluoro-2'-deoxyuridine (FUdR; FUDR), the active metabolite of fluorouracil (5-FU), an antimetabolite fluoropyrimidine analog of the pyrimidine nucleoside, with potential antineoplastic activity. Upon administration of the nucleotide analog prodrug fosifloxuridine nafalbenamide, fosifloxuridine nafalbenamide is readily taken up by tumor cells. In the tumor cell, the phosphoramidate moiety is removed and fosifloxuridine nafalbenamide is converted to its active form FUDR-MP. In turn, FUDR-MP binds to and inhibits thymidylate synthase (TS), resulting in the depletion of thymidine triphosphate (TTP) and thus DNA synthesis. With the phosphoramidate moiety attached to FUDR-MP, fosifloxuridine nafalbenamide, compared to 5-FU, is more lipophilic and accumulates in cancer cells by passive diffusion and does not require a nucleoside transporter, thereby generating higher intracellular concentrations. In addition, compared to 5-FU, once inside the cell FUDR-MP does not need to be phosphorylated and is already in its active form. Unlike 5-FU, fosifloxuridine nafalbenamide does not get deactivated or converted into toxic metabolites by dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP), which leads to both a longer half-life and less toxicity." @default.
- NCIT_C156680 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156680 NCIT_A7 NCIT_C17199 @default.
- NCIT_C156680 NCIT_NHC0 "C156680" @default.
- NCIT_C156680 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C156680 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156680 NCIT_P107 "Fosifloxuridine Nafalbenamide" @default.
- NCIT_C156680 NCIT_P108 "Fosifloxuridine Nafalbenamide" @default.
- NCIT_C156680 NCIT_P208 "CL935731" @default.
- NCIT_C156680 NCIT_P210 "1332837-31-6" @default.
- NCIT_C156680 NCIT_P319 "4YO6QT3SZ9" @default.
- NCIT_C156680 NCIT_P322 "CTRP" @default.
- NCIT_C156680 NCIT_P322 "FDA" @default.
- NCIT_C156680 NCIT_P322 "GDC" @default.
- NCIT_C156680 NCIT_P329 "795584" @default.
- NCIT_C156680 NCIT_P330 "795584" @default.
- NCIT_C156680 NCIT_P375 "Fosifloxuridine Nafalbenamide" @default.
- NCIT_C156680 NCIT_P375 "Nucleotide Analog Prodrug NUC-3373" @default.
- NCIT_C156680 NCIT_P399 "795584" @default.
- NCIT_C156680 normalizedInformationContent "100" @default.
- NCIT_C156680 referenceCount "1" @default.
- NCIT_C156680 hasExactSynonym "5-FU Analog Prodrug NUC-3373" @default.
- NCIT_C156680 hasExactSynonym "FOSIFLOXURIDINE NAFALBENAMIDE" @default.
- NCIT_C156680 hasExactSynonym "Fosifloxuridine Nafalbenamide" @default.
- NCIT_C156680 hasExactSynonym "L-Alanine, N-(-2'-Deoxy-2',2'-difluoro-p-1-naphthalenyl-5'-cytidylyl)-, Phenylmethyl Ester" @default.
- NCIT_C156680 hasExactSynonym "NUC 3373" @default.
- NCIT_C156680 hasExactSynonym "NUC-3373" @default.
- NCIT_C156680 hasExactSynonym "NUC3373" @default.
- NCIT_C156680 hasExactSynonym "Nucleotide Analog NUC-3373" @default.
- NCIT_C156680 hasExactSynonym "Phosphoramidate-FUDR-MP Prodrug NUC-3373" @default.
- NCIT_C156680 inSubset NCIT_C116977 @default.
- NCIT_C156680 inSubset NCIT_C116978 @default.
- NCIT_C156680 inSubset NCIT_C128784 @default.
- NCIT_C156680 inSubset NCIT_C157711 @default.
- NCIT_C156680 inSubset NCIT_C157712 @default.
- NCIT_C156680 inSubset NCIT_C176424 @default.
- NCIT_C156680 inSubset NCIT_C177537 @default.
- NCIT_C156680 inSubset NCIT_C63923 @default.
- NCIT_C156680 type Class @default.
- NCIT_C156680 isDefinedBy ncit.owl @default.
- NCIT_C156680 label "Fosifloxuridine Nafalbenamide" @default.
- NCIT_C156680 subClassOf NCIT_C1557 @default.
- NCIT_C156680 subClassOf NCIT_C156680 @default.
- NCIT_C156680 subClassOf NCIT_C186664 @default.
- NCIT_C156680 subClassOf NCIT_C1908 @default.
- NCIT_C156680 subClassOf NCIT_C1909 @default.
- NCIT_C156680 subClassOf NCIT_C2021 @default.
- NCIT_C156680 subClassOf NCIT_C272 @default.
- NCIT_C156680 subClassOf NCIT_C274 @default.
- NCIT_C156680 subClassOf NCIT_C471 @default.