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- NCIT_C156681 IAO_0000115 "A recombinant antibody derivative composed of tri-specific T-cell activating construct (TriTAC) directed against the human tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA; FOLH1) and the CD3 antigen found on T-lymphocytes and an albumin-binding domain, with potential immunostimulating and antineoplastic activities. Upon administration, PSMA/CD3 tri-specific T-cell antibody construct HPN424 targets and binds PSMA on tumor cells and CD3 on cytotoxic T-lymphocytes (CTLs), thereby bringing PSMA-expressing tumor cells and CTLs together, which results in the CTL-mediated cell death of PSMA-expressing tumor cells. The albumin-binding domain targets and binds to serum albumin, thereby extending the serum half-life of HPN424. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate tumor cells." @default.
- NCIT_C156681 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156681 NCIT_A7 NCIT_C17796 @default.
- NCIT_C156681 NCIT_NHC0 "C156681" @default.
- NCIT_C156681 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156681 NCIT_P107 "PSMA/CD3 Tri-specific T-cell Activating Construct HPN424" @default.
- NCIT_C156681 NCIT_P108 "PSMA/CD3 Tri-specific T-cell Activating Construct HPN424" @default.
- NCIT_C156681 NCIT_P208 "CL935732" @default.
- NCIT_C156681 NCIT_P319 "ZAA5KE2UAS" @default.
- NCIT_C156681 NCIT_P322 "CTRP" @default.
- NCIT_C156681 NCIT_P322 "FDA" @default.
- NCIT_C156681 NCIT_P322 "GDC" @default.
- NCIT_C156681 NCIT_P329 "795833" @default.
- NCIT_C156681 NCIT_P330 "795833" @default.
- NCIT_C156681 NCIT_P375 "PSMA/CD3 Tri-specific T-cell Activating Construct HPN424" @default.
- NCIT_C156681 NCIT_P399 "795833" @default.
- NCIT_C156681 normalizedInformationContent "100" @default.
- NCIT_C156681 referenceCount "1" @default.
- NCIT_C156681 hasExactSynonym "Anti-PSMA/CD3 TriTAC HPN424" @default.
- NCIT_C156681 hasExactSynonym "HPN 424" @default.
- NCIT_C156681 hasExactSynonym "HPN-424" @default.
- NCIT_C156681 hasExactSynonym "HPN424" @default.
- NCIT_C156681 hasExactSynonym "PSMA/CD3 Tri-specific T-cell Activating Construct HPN424" @default.
- NCIT_C156681 hasExactSynonym "PSMA/CD3 TriTAC HPN424" @default.
- NCIT_C156681 hasExactSynonym "PSMA/CD3-specific TriTAC HPN424" @default.
- NCIT_C156681 hasExactSynonym "TriTAC HPN424" @default.
- NCIT_C156681 inSubset NCIT_C116977 @default.
- NCIT_C156681 inSubset NCIT_C116978 @default.
- NCIT_C156681 inSubset NCIT_C128784 @default.
- NCIT_C156681 inSubset NCIT_C157711 @default.
- NCIT_C156681 inSubset NCIT_C157712 @default.
- NCIT_C156681 inSubset NCIT_C176424 @default.
- NCIT_C156681 inSubset NCIT_C177537 @default.
- NCIT_C156681 inSubset NCIT_C63923 @default.
- NCIT_C156681 type Class @default.
- NCIT_C156681 isDefinedBy ncit.owl @default.
- NCIT_C156681 label "PSMA/CD3 Tri-specific T-cell Activating Construct HPN424" @default.
- NCIT_C156681 subClassOf NCIT_C129820 @default.
- NCIT_C156681 subClassOf NCIT_C156681 @default.
- NCIT_C156681 subClassOf NCIT_C163758 @default.
- NCIT_C156681 subClassOf NCIT_C176017 @default.
- NCIT_C156681 subClassOf NCIT_C1908 @default.
- NCIT_C156681 subClassOf NCIT_C1909 @default.
- NCIT_C156681 subClassOf NCIT_C274 @default.
- NCIT_C156681 subClassOf NCIT_C308 @default.