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- NCIT_C156692 IAO_0000115 "A humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, benmelstobart specifically targets and binds to PD-L1, preventing the binding and subsequent activation of its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This reverses T-cell inactivation caused by PD-L1/PD-1 signaling, increases T-cell expansion and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1, a transmembrane protein expressed on activated T-cells, is overexpressed in some cancer types and plays a significant role in immune evasion by tumor cells." @default.
- NCIT_C156692 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156692 NCIT_A7 NCIT_C96024 @default.
- NCIT_C156692 NCIT_NHC0 "C156692" @default.
- NCIT_C156692 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156692 NCIT_P108 "Benmelstobart" @default.
- NCIT_C156692 NCIT_P208 "CL935711" @default.
- NCIT_C156692 NCIT_P210 "2303884-58-2" @default.
- NCIT_C156692 NCIT_P319 "B25CF42QKP" @default.
- NCIT_C156692 NCIT_P322 "FDA" @default.
- NCIT_C156692 NCIT_P322 "GDC" @default.
- NCIT_C156692 NCIT_P329 "795708" @default.
- NCIT_C156692 NCIT_P330 "795708" @default.
- NCIT_C156692 NCIT_P375 "Anti-PD-L1 Monoclonal Antibody CBT-502" @default.
- NCIT_C156692 NCIT_P399 "795708" @default.
- NCIT_C156692 NCIT_R124 NCIT_C17710 @default.
- NCIT_C156692 NCIT_R124 NCIT_C17828 @default.
- NCIT_C156692 NCIT_R124 NCIT_C18219 @default.
- NCIT_C156692 NCIT_R124 NCIT_C19986 @default.
- NCIT_C156692 NCIT_R124 NCIT_C40474 @default.
- NCIT_C156692 normalizedInformationContent "100" @default.
- NCIT_C156692 referenceCount "1" @default.
- NCIT_C156692 hasExactSynonym "APL502" @default.
- NCIT_C156692 hasExactSynonym "Anti-PD-L1 Monoclonal Antibody CBT-502" @default.
- NCIT_C156692 hasExactSynonym "Anti-PD-L1 Monoclonal Antibody TQB2450" @default.
- NCIT_C156692 hasExactSynonym "BENMELSTOBART" @default.
- NCIT_C156692 hasExactSynonym "Benmelstobart" @default.
- NCIT_C156692 hasExactSynonym "CBT 502" @default.
- NCIT_C156692 hasExactSynonym "CBT-502" @default.
- NCIT_C156692 hasExactSynonym "CBT502" @default.
- NCIT_C156692 hasExactSynonym "TQB 2450" @default.
- NCIT_C156692 hasExactSynonym "TQB-2450" @default.
- NCIT_C156692 hasExactSynonym "TQB2450" @default.
- NCIT_C156692 inSubset NCIT_C128784 @default.
- NCIT_C156692 inSubset NCIT_C157711 @default.
- NCIT_C156692 inSubset NCIT_C157712 @default.
- NCIT_C156692 inSubset NCIT_C176424 @default.
- NCIT_C156692 inSubset NCIT_C177537 @default.
- NCIT_C156692 inSubset NCIT_C63923 @default.
- NCIT_C156692 type Class @default.
- NCIT_C156692 isDefinedBy ncit.owl @default.
- NCIT_C156692 label "Benmelstobart" @default.
- NCIT_C156692 subClassOf NCIT_C128057 @default.
- NCIT_C156692 subClassOf NCIT_C129821 @default.
- NCIT_C156692 subClassOf NCIT_C129822 @default.
- NCIT_C156692 subClassOf NCIT_C141144 @default.
- NCIT_C156692 subClassOf NCIT_C143250 @default.
- NCIT_C156692 subClassOf NCIT_C156692 @default.
- NCIT_C156692 subClassOf NCIT_C156893 @default.
- NCIT_C156692 subClassOf NCIT_C163758 @default.
- NCIT_C156692 subClassOf NCIT_C1908 @default.
- NCIT_C156692 subClassOf NCIT_C1909 @default.
- NCIT_C156692 subClassOf NCIT_C191689 @default.
- NCIT_C156692 subClassOf NCIT_C20401 @default.
- NCIT_C156692 subClassOf NCIT_C274 @default.
- NCIT_C156692 subClassOf NCIT_C307 @default.
- NCIT_C156692 subClassOf NCIT_C308 @default.