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- NCIT_C156705 IAO_0000115 "An anti-human epidermal growth factor receptor 2 (HER2)/anti-CD3 T-cell-dependent bispecific (TDB) monoclonal antibody with potential immunostimulatory and antineoplastic activities. Upon administration, runimotamab possesses two antigen recognition sites, one for HER2, a tyrosine kinase receptor overexpressed by many cancer cell types, and one for the CD3 complex, a group of T-cell surface glycoproteins that interact with the T-cell receptor (TCR). Upon administration of runimotamab, this bispecific monoclonal antibody simultaneously binds to both CD3-expressing T-cells and HER2-expressing cancer cells, thereby crosslinking HER2-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This may result in potent CTL-mediated lysis of HER2-expressing tumor cells. HER2 plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C156705 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156705 NCIT_NHC0 "C156705" @default.
- NCIT_C156705 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C156705 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156705 NCIT_P108 "Runimotamab" @default.
- NCIT_C156705 NCIT_P208 "CL935873" @default.
- NCIT_C156705 NCIT_P210 "2361325-98-4" @default.
- NCIT_C156705 NCIT_P319 "F8Z9VSZ0K1" @default.
- NCIT_C156705 NCIT_P322 "FDA" @default.
- NCIT_C156705 NCIT_P322 "GDC" @default.
- NCIT_C156705 NCIT_P329 "795725" @default.
- NCIT_C156705 NCIT_P330 "795725" @default.
- NCIT_C156705 NCIT_P375 "Anti-HER2/Anti-CD3 Bispecific Monoclonal Antibody BTRC 4017A" @default.
- NCIT_C156705 NCIT_P399 "795725" @default.
- NCIT_C156705 NCIT_R124 NCIT_C17710 @default.
- NCIT_C156705 NCIT_R124 NCIT_C17828 @default.
- NCIT_C156705 NCIT_R124 NCIT_C18219 @default.
- NCIT_C156705 NCIT_R124 NCIT_C19986 @default.
- NCIT_C156705 NCIT_R124 NCIT_C40474 @default.
- NCIT_C156705 normalizedInformationContent "100" @default.
- NCIT_C156705 referenceCount "1" @default.
- NCIT_C156705 hasExactSynonym "Anti-HER2 x Anti-CD3 Bispecific Monoclonal Antibody BTRC 4017A" @default.
- NCIT_C156705 hasExactSynonym "Anti-HER2 x Anti-CD3 Bispecific Monoclonal Antibody RG 6194" @default.
- NCIT_C156705 hasExactSynonym "Anti-HER2/Anti-CD3 Bispecific Monoclonal Antibody 4017A" @default.
- NCIT_C156705 hasExactSynonym "Anti-HER2/Anti-CD3 Bispecific Monoclonal Antibody BTRC 4017A" @default.
- NCIT_C156705 hasExactSynonym "BTRC 4017A" @default.
- NCIT_C156705 hasExactSynonym "BTRC-4017A" @default.
- NCIT_C156705 hasExactSynonym "BTRC4017A" @default.
- NCIT_C156705 hasExactSynonym "RG 6194" @default.
- NCIT_C156705 hasExactSynonym "RG-6194" @default.
- NCIT_C156705 hasExactSynonym "RG6194" @default.
- NCIT_C156705 hasExactSynonym "RUNIMOTAMAB" @default.
- NCIT_C156705 hasExactSynonym "Runimotamab" @default.
- NCIT_C156705 inSubset NCIT_C128784 @default.
- NCIT_C156705 inSubset NCIT_C157711 @default.
- NCIT_C156705 inSubset NCIT_C157712 @default.
- NCIT_C156705 inSubset NCIT_C176424 @default.
- NCIT_C156705 inSubset NCIT_C177537 @default.
- NCIT_C156705 inSubset NCIT_C63923 @default.
- NCIT_C156705 type Class @default.
- NCIT_C156705 isDefinedBy ncit.owl @default.
- NCIT_C156705 label "Runimotamab" @default.
- NCIT_C156705 subClassOf NCIT_C112883 @default.
- NCIT_C156705 subClassOf NCIT_C129821 @default.
- NCIT_C156705 subClassOf NCIT_C129822 @default.
- NCIT_C156705 subClassOf NCIT_C1454 @default.
- NCIT_C156705 subClassOf NCIT_C155711 @default.
- NCIT_C156705 subClassOf NCIT_C156705 @default.
- NCIT_C156705 subClassOf NCIT_C163758 @default.
- NCIT_C156705 subClassOf NCIT_C163760 @default.
- NCIT_C156705 subClassOf NCIT_C1908 @default.
- NCIT_C156705 subClassOf NCIT_C1909 @default.
- NCIT_C156705 subClassOf NCIT_C201282 @default.
- NCIT_C156705 subClassOf NCIT_C20401 @default.
- NCIT_C156705 subClassOf NCIT_C274 @default.
- NCIT_C156705 subClassOf NCIT_C28227 @default.
- NCIT_C156705 subClassOf NCIT_C307 @default.
- NCIT_C156705 subClassOf NCIT_C308 @default.