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- NCIT_C156707 IAO_0000115 "An antibody-drug conjugate (ADC) comprised of a full-length, fully-human immunoglobulin G1 (IgG1) monoclonal antibody (mAb) directed against the extracellular domain of guanylyl cyclase C (GCC; GUCY2C), conjugated using the peptide-linked indolino-benzodiazepine DNA alkylator DGN549 (IGN-P1), with potential antineoplastic activity. Upon intravenous administration of TAK-164, the antibody moiety selectively binds to GCC-expressing cells. Upon antibody/antigen binding and internalization, the cytotoxic DGN549 payload is released and binds to guanine residues on opposing strands of DNA. This induces DNA strand breaks, inhibits DNA replication, leads to G2/M cell cycle arrest, induces cell death, and inhibits the proliferation of GCC-expressing cells. GCC, a transmembrane receptor normally found on intestinal cells and dopamine neurons in the brain, is overexpressed on the surface of certain tumor cells." @default.
- NCIT_C156707 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156707 NCIT_A7 NCIT_C123877 @default.
- NCIT_C156707 NCIT_NHC0 "C156707" @default.
- NCIT_C156707 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156707 NCIT_P107 "Anti-GCC Antibody-Drug Conjugate TAK-164" @default.
- NCIT_C156707 NCIT_P108 "Anti-GCC Antibody-Drug Conjugate TAK-164" @default.
- NCIT_C156707 NCIT_P208 "CL935871" @default.
- NCIT_C156707 NCIT_P319 "QCA97P3GSS" @default.
- NCIT_C156707 NCIT_P322 "CTRP" @default.
- NCIT_C156707 NCIT_P322 "FDA" @default.
- NCIT_C156707 NCIT_P322 "GDC" @default.
- NCIT_C156707 NCIT_P329 "795729" @default.
- NCIT_C156707 NCIT_P330 "795729" @default.
- NCIT_C156707 NCIT_P375 "Anti-GCC Antibody-Drug Conjugate TAK-164" @default.
- NCIT_C156707 NCIT_P399 "795729" @default.
- NCIT_C156707 normalizedInformationContent "100" @default.
- NCIT_C156707 referenceCount "1" @default.
- NCIT_C156707 hasExactSynonym "Anti-GCC ADC TAK-164" @default.
- NCIT_C156707 hasExactSynonym "Anti-GCC Antibody-Drug Conjugate TAK-164" @default.
- NCIT_C156707 hasExactSynonym "TAK 164" @default.
- NCIT_C156707 hasExactSynonym "TAK-164" @default.
- NCIT_C156707 hasExactSynonym "TAK164" @default.
- NCIT_C156707 inSubset NCIT_C116977 @default.
- NCIT_C156707 inSubset NCIT_C116978 @default.
- NCIT_C156707 inSubset NCIT_C128784 @default.
- NCIT_C156707 inSubset NCIT_C157711 @default.
- NCIT_C156707 inSubset NCIT_C157712 @default.
- NCIT_C156707 inSubset NCIT_C176424 @default.
- NCIT_C156707 inSubset NCIT_C177537 @default.
- NCIT_C156707 inSubset NCIT_C63923 @default.
- NCIT_C156707 type Class @default.
- NCIT_C156707 isDefinedBy ncit.owl @default.
- NCIT_C156707 label "Anti-GCC Antibody-Drug Conjugate TAK-164" @default.
- NCIT_C156707 subClassOf NCIT_C129821 @default.
- NCIT_C156707 subClassOf NCIT_C129823 @default.
- NCIT_C156707 subClassOf NCIT_C1512 @default.
- NCIT_C156707 subClassOf NCIT_C156707 @default.
- NCIT_C156707 subClassOf NCIT_C1908 @default.
- NCIT_C156707 subClassOf NCIT_C1909 @default.
- NCIT_C156707 subClassOf NCIT_C274 @default.
- NCIT_C156707 subClassOf NCIT_C307 @default.
- NCIT_C156707 subClassOf NCIT_C308 @default.