Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C156730> ?p ?o ?g. }
Showing items 1 to 41 of
41
with 100 items per page.
- NCIT_C156730 IAO_0000115 "An orally available small molecule antagonist of the C-X-C motif chemokine receptor 1 (CXCR1; interleukin-8 receptor alpha; IL8RA) and 2 (CXCR2; interleukin-8 receptor beta; IL8RB), with potential immunomodulating and antineoplastic activities. Upon administration, navarixin binds to and inhibits the activation of CXCR 1 and 2. This inhibits CXCR1/2-mediated signaling, reduces both recruitment and migration of immunosuppressive myeloid-derived suppressor cells (MDSCs) and neutrophils in the tumor microenvironment (TME), inhibits inflammatory processes and abrogates the immunosuppressive nature of the TME. This allows effector cells, such as natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs), to kill and eliminate cancer cells. This inhibits tumor cell migration, metastasis, angiogenesis and tumor cell proliferation. CXCR 1 and 2, G protein-coupled receptor proteins located on myeloid cells and certain tumor cells, play key roles in the immunosuppressive nature of the TME, tumor metastasis, therapy-resistance, myeloid cell suppression, and inflammation." @default.
- NCIT_C156730 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156730 NCIT_NHC0 "C156730" @default.
- NCIT_C156730 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156730 NCIT_P107 "CCR2 Antagonist PF-04136309" @default.
- NCIT_C156730 NCIT_P107 "Navarixin" @default.
- NCIT_C156730 NCIT_P108 "Navarixin" @default.
- NCIT_C156730 NCIT_P208 "CL935858" @default.
- NCIT_C156730 NCIT_P210 "862464-58-2" @default.
- NCIT_C156730 NCIT_P319 "7V3BY6G538" @default.
- NCIT_C156730 NCIT_P322 "CTRP" @default.
- NCIT_C156730 NCIT_P322 "FDA" @default.
- NCIT_C156730 NCIT_P322 "GDC" @default.
- NCIT_C156730 NCIT_P329 "795588" @default.
- NCIT_C156730 NCIT_P330 "795588" @default.
- NCIT_C156730 NCIT_P375 "Navarixin" @default.
- NCIT_C156730 NCIT_P399 "795588" @default.
- NCIT_C156730 normalizedInformationContent "100" @default.
- NCIT_C156730 referenceCount "1" @default.
- NCIT_C156730 hasExactSynonym "2-Hydroxy-N,N-dimethyl-3-((2-((1R)-1-(5-methylfuran-2-yl)propyl)amine)-3,4- dioxocyclobut-1-enyl)amino)benzamide Monohydrate" @default.
- NCIT_C156730 hasExactSynonym "MK-7123" @default.
- NCIT_C156730 hasExactSynonym "NAVARIXIN" @default.
- NCIT_C156730 hasExactSynonym "Navarixin" @default.
- NCIT_C156730 hasExactSynonym "PS291822" @default.
- NCIT_C156730 hasExactSynonym "SCH 527123" @default.
- NCIT_C156730 inSubset NCIT_C116977 @default.
- NCIT_C156730 inSubset NCIT_C116978 @default.
- NCIT_C156730 inSubset NCIT_C128784 @default.
- NCIT_C156730 inSubset NCIT_C157711 @default.
- NCIT_C156730 inSubset NCIT_C157712 @default.
- NCIT_C156730 inSubset NCIT_C176424 @default.
- NCIT_C156730 inSubset NCIT_C177537 @default.
- NCIT_C156730 inSubset NCIT_C63923 @default.
- NCIT_C156730 type Class @default.
- NCIT_C156730 isDefinedBy ncit.owl @default.
- NCIT_C156730 label "Navarixin" @default.
- NCIT_C156730 subClassOf NCIT_C156730 @default.
- NCIT_C156730 subClassOf NCIT_C1908 @default.
- NCIT_C156730 subClassOf NCIT_C1909 @default.
- NCIT_C156730 subClassOf NCIT_C308 @default.
- NCIT_C156730 subClassOf NCIT_C63817 @default.