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- NCIT_C156732 IAO_0000115 "A recombinant, plasmid DNA expression vector encoding a 39 nucleotide (nt) short hairpin RNA (shRNA) specific for the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon intratumoral administration, the EGFR antisense DNA BB-401 is taken up by tumor cells and shRNA is transcribed. The shRNA is converted into small interfering RNA (siRNA) via the RNA interference (RNAi) pathway. The siRNA targets and binds to EGFR RNA expressed by tumor cells. This blocks EGFR mRNA translation and prevents EGFR protein expression." @default.
- NCIT_C156732 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156732 NCIT_NHC0 "C156732" @default.
- NCIT_C156732 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C156732 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156732 NCIT_P108 "EGFR Antisense DNA BB-401" @default.
- NCIT_C156732 NCIT_P208 "CL935856" @default.
- NCIT_C156732 NCIT_P322 "GDC" @default.
- NCIT_C156732 NCIT_P329 "795589" @default.
- NCIT_C156732 NCIT_P330 "795589" @default.
- NCIT_C156732 NCIT_P375 "EGFR Antisense DNA BB-401" @default.
- NCIT_C156732 NCIT_P399 "795589" @default.
- NCIT_C156732 normalizedInformationContent "100" @default.
- NCIT_C156732 referenceCount "1" @default.
- NCIT_C156732 hasExactSynonym "Anti-EGFR ddRNAi BB-401" @default.
- NCIT_C156732 hasExactSynonym "BB 401" @default.
- NCIT_C156732 hasExactSynonym "BB-401" @default.
- NCIT_C156732 hasExactSynonym "BB401" @default.
- NCIT_C156732 hasExactSynonym "EGFR Antisense DNA BB-401" @default.
- NCIT_C156732 hasExactSynonym "ddRNAi BB-401" @default.
- NCIT_C156732 inSubset NCIT_C128784 @default.
- NCIT_C156732 inSubset NCIT_C157711 @default.
- NCIT_C156732 inSubset NCIT_C157712 @default.
- NCIT_C156732 inSubset NCIT_C176424 @default.
- NCIT_C156732 inSubset NCIT_C177537 @default.
- NCIT_C156732 type Class @default.
- NCIT_C156732 isDefinedBy ncit.owl @default.
- NCIT_C156732 label "EGFR Antisense DNA BB-401" @default.
- NCIT_C156732 subClassOf NCIT_C1291 @default.
- NCIT_C156732 subClassOf NCIT_C156732 @default.
- NCIT_C156732 subClassOf NCIT_C1908 @default.
- NCIT_C156732 subClassOf NCIT_C1909 @default.
- NCIT_C156732 subClassOf NCIT_C1962 @default.
- NCIT_C156732 subClassOf NCIT_C307 @default.