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- NCIT_C156737 IAO_0000115 "An orally available, small-molecule inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1; receptor-interacting protein 1; RIP1) with potential antineoplastic and immunomodulatory activities. Upon administration, GSK3145095 disrupts RIPK1-mediated signaling, which may reduce C-X-C motif chemokine ligand 1 (CXCL1)-driven recruitment and migration of immunosuppressive myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TME). This allows effector cells, such as natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs), to kill and eliminate cancer cells. RIPK1, a serine-threonine kinase that normally plays a key role in inflammation and cell death in response to tissue damage and pathogen recognition, is overexpressed in certain cancer types and may be associated with oncogenesis and promotion of the immunosuppressive nature of the TME." @default.
- NCIT_C156737 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156737 NCIT_A7 NCIT_C17923 @default.
- NCIT_C156737 NCIT_NHC0 "C156737" @default.
- NCIT_C156737 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156737 NCIT_P107 "RIPK1 Inhibitor GSK3145095" @default.
- NCIT_C156737 NCIT_P108 "RIPK1 Inhibitor GSK3145095" @default.
- NCIT_C156737 NCIT_P208 "CL935900" @default.
- NCIT_C156737 NCIT_P210 "1622849-43-7" @default.
- NCIT_C156737 NCIT_P319 "B4D3WPS7JY" @default.
- NCIT_C156737 NCIT_P322 "CTRP" @default.
- NCIT_C156737 NCIT_P322 "FDA" @default.
- NCIT_C156737 NCIT_P322 "GDC" @default.
- NCIT_C156737 NCIT_P329 "795835" @default.
- NCIT_C156737 NCIT_P330 "795835" @default.
- NCIT_C156737 NCIT_P375 "RIPK1 Inhibitor GSK3145095" @default.
- NCIT_C156737 NCIT_P399 "795835" @default.
- NCIT_C156737 normalizedInformationContent "100" @default.
- NCIT_C156737 referenceCount "1" @default.
- NCIT_C156737 hasExactSynonym "GSK 3145095" @default.
- NCIT_C156737 hasExactSynonym "GSK-3145095" @default.
- NCIT_C156737 hasExactSynonym "GSK3145095" @default.
- NCIT_C156737 hasExactSynonym "RIPK1 Inhibitor GSK3145095" @default.
- NCIT_C156737 hasExactSynonym "Receptor-interacting Serine/Threonine-protein Kinase 1 Inhibitor GSK3145095" @default.
- NCIT_C156737 inSubset NCIT_C116977 @default.
- NCIT_C156737 inSubset NCIT_C116978 @default.
- NCIT_C156737 inSubset NCIT_C128784 @default.
- NCIT_C156737 inSubset NCIT_C157711 @default.
- NCIT_C156737 inSubset NCIT_C157712 @default.
- NCIT_C156737 inSubset NCIT_C176424 @default.
- NCIT_C156737 inSubset NCIT_C177537 @default.
- NCIT_C156737 inSubset NCIT_C63923 @default.
- NCIT_C156737 type Class @default.
- NCIT_C156737 isDefinedBy ncit.owl @default.
- NCIT_C156737 label "RIPK1 Inhibitor GSK3145095" @default.
- NCIT_C156737 subClassOf NCIT_C129824 @default.
- NCIT_C156737 subClassOf NCIT_C129825 @default.
- NCIT_C156737 subClassOf NCIT_C156737 @default.
- NCIT_C156737 subClassOf NCIT_C1908 @default.
- NCIT_C156737 subClassOf NCIT_C1909 @default.
- NCIT_C156737 subClassOf NCIT_C2189 @default.
- NCIT_C156737 subClassOf NCIT_C274 @default.
- NCIT_C156737 subClassOf NCIT_C471 @default.