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- NCIT_C156739 IAO_0000115 "A radioconjugate composed of a tumor-selective fluorescent imaging agent containing silica-based nanoparticles labeled with a near-infrared (NIR) fluorophore, cyanine 5 (Cy5), and surrounded by polyethylene glycol (PEG) chains attached to cyclic arginine-glycine-aspartic acid-tyrosine) (cyclo-(Arg-Gly-Asp-Tyr; cRGDY) peptides (C' dots; Cornell prime dots; cRGDY-PEG-C' dots), and linked, via the chelator desferrioxamine (DFO), to the radioisotope zirconium Zr 89 (Zr89), with potential diagnostic properties upon positron emission tomography (PET) imaging. Upon intradermal administration of the zirconium Zr 89 cRGDY PEG-Cy5-C' dots, the cRGDY moiety selectively binds to alphaVbeta3 integrin expressed on tumor cells. Upon binding, the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of integrin-expressing tumor cells as well as the visualization of the distribution, uptake and removal within tumor tissues. The fluorescence imaging agent is used to visualize alphaVbeta3-expressing tumor cells and assess the degree of both tumor metastasis and sentinel lymph node (SLN) trafficking. Integrins are transmembrane glycoproteins upregulated on proliferating tumor vessel endothelial cells and various cancer cells; their overexpression has been associated with neovascularization, differentiation, proliferation of tumor cells, metastasis and an overall poor prognosis." @default.
- NCIT_C156739 NCIT_NHC0 "C156739" @default.
- NCIT_C156739 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C156739 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C156739 NCIT_P108 "Zirconium Zr 89-DFO-cRGDY PEG-Cy5-C' Dots" @default.
- NCIT_C156739 NCIT_P208 "CL935906" @default.
- NCIT_C156739 NCIT_P329 "795696" @default.
- NCIT_C156739 NCIT_P330 "795696" @default.
- NCIT_C156739 NCIT_P399 "795696" @default.
- NCIT_C156739 normalizedInformationContent "100" @default.
- NCIT_C156739 referenceCount "1" @default.
- NCIT_C156739 hasExactSynonym "89Zr-DFO-cRGDY-PEG-Cy5-C' Dot Nanoparticles" @default.
- NCIT_C156739 hasExactSynonym "89Zr-DFO-cRGDY-PEG-Cy5-C' Dot Particles" @default.
- NCIT_C156739 hasExactSynonym "89Zr-DFO-cRGDY-PEG-Cy5-C' Dots" @default.
- NCIT_C156739 hasExactSynonym "Zirconium Zr 89-DFO-cRGDY PEG-Cy5-C' Dots" @default.
- NCIT_C156739 hasExactSynonym "Zr 89-DFO-cRGDY PEG-Cy5-C' Dots" @default.
- NCIT_C156739 inSubset NCIT_C176424 @default.
- NCIT_C156739 type Class @default.
- NCIT_C156739 isDefinedBy ncit.owl @default.
- NCIT_C156739 label "Zirconium Zr 89-DFO-cRGDY PEG-Cy5-C' Dots" @default.
- NCIT_C156739 subClassOf NCIT_C1446 @default.
- NCIT_C156739 subClassOf NCIT_C1511 @default.
- NCIT_C156739 subClassOf NCIT_C1512 @default.
- NCIT_C156739 subClassOf NCIT_C156739 @default.
- NCIT_C156739 subClassOf NCIT_C1908 @default.
- NCIT_C156739 subClassOf NCIT_C1909 @default.
- NCIT_C156739 subClassOf NCIT_C2124 @default.
- NCIT_C156739 subClassOf NCIT_C307 @default.
- NCIT_C156739 subClassOf NCIT_C308 @default.