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- NCIT_C156740 IAO_0000115 "An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor AMG 397 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival." @default.
- NCIT_C156740 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156740 NCIT_NHC0 "C156740" @default.
- NCIT_C156740 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156740 NCIT_P107 "Murizatoclax" @default.
- NCIT_C156740 NCIT_P108 "Murizatoclax" @default.
- NCIT_C156740 NCIT_P208 "CL935903" @default.
- NCIT_C156740 NCIT_P210 "2245848-05-7" @default.
- NCIT_C156740 NCIT_P319 "BO0V7196L2" @default.
- NCIT_C156740 NCIT_P322 "CTRP" @default.
- NCIT_C156740 NCIT_P322 "FDA" @default.
- NCIT_C156740 NCIT_P322 "GDC" @default.
- NCIT_C156740 NCIT_P329 "795697" @default.
- NCIT_C156740 NCIT_P330 "795697" @default.
- NCIT_C156740 NCIT_P375 "MCL-1 inhibitor AMG 397" @default.
- NCIT_C156740 NCIT_P375 "Murizatoclax" @default.
- NCIT_C156740 NCIT_P399 "795697" @default.
- NCIT_C156740 normalizedInformationContent "100" @default.
- NCIT_C156740 referenceCount "1" @default.
- NCIT_C156740 hasExactSynonym "AMG 397" @default.
- NCIT_C156740 hasExactSynonym "AMG-397" @default.
- NCIT_C156740 hasExactSynonym "AMG397" @default.
- NCIT_C156740 hasExactSynonym "MCL-1 inhibitor AMG 397" @default.
- NCIT_C156740 hasExactSynonym "MURIZATOCLAX" @default.
- NCIT_C156740 hasExactSynonym "Murizatoclax" @default.
- NCIT_C156740 hasExactSynonym "Myeloid Cell Leukemia 1 Inhibitor AMG 397" @default.
- NCIT_C156740 inSubset NCIT_C116977 @default.
- NCIT_C156740 inSubset NCIT_C116978 @default.
- NCIT_C156740 inSubset NCIT_C128784 @default.
- NCIT_C156740 inSubset NCIT_C157711 @default.
- NCIT_C156740 inSubset NCIT_C157712 @default.
- NCIT_C156740 inSubset NCIT_C176424 @default.
- NCIT_C156740 inSubset NCIT_C177537 @default.
- NCIT_C156740 inSubset NCIT_C63923 @default.
- NCIT_C156740 type Class @default.
- NCIT_C156740 isDefinedBy ncit.owl @default.
- NCIT_C156740 label "Murizatoclax" @default.
- NCIT_C156740 subClassOf NCIT_C129839 @default.
- NCIT_C156740 subClassOf NCIT_C137990 @default.
- NCIT_C156740 subClassOf NCIT_C156740 @default.
- NCIT_C156740 subClassOf NCIT_C1908 @default.
- NCIT_C156740 subClassOf NCIT_C1909 @default.
- NCIT_C156740 subClassOf NCIT_C192025 @default.
- NCIT_C156740 subClassOf NCIT_C274 @default.