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- NCIT_C156772 IAO_0000115 "A radioconjugate containing LLP2A, a high-affinity peptidomimetic ligand for the tumor-associated antigen (TAA) very-late-antigen-4 (VLA-4; VLA 4; alpha4beta1 integrin; CD49d/CD29), conjugated, via the chelator 1,4,8,11-tetraazacyclotetradecane-1-(methane phosphonic acid)-8-(methane carboxylic acid) (CB-TE1A1P), to the radioisotope copper Cu 64, and conjugated to polyethylene glycol (PEG) chains that can potentially be used as a diagnostic imaging agent of VLA-4-expressing tumor cells using positron-emitting tomography (PET). Upon administration, copper Cu 64-CB-TE1A1P-PEG4-LLP2A targets, binds to and is taken up by VLA-4-expressing tumor cells. Upon PET, the VLA-4-expressing tumor cells can be visualized, and the tumor can be assessed. VLA-4, a transmembrane adhesion receptor overexpressed and activated on various tumor cell types and surrounding stroma, plays an important role in tumor growth, angiogenesis, metastasis, drug resistance and immune responses. Pegylation optimizes the pharmacokinetic profile of 64Cu-LLP2A." @default.
- NCIT_C156772 NCIT_A7 NCIT_C97745 @default.
- NCIT_C156772 NCIT_NHC0 "C156772" @default.
- NCIT_C156772 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156772 NCIT_P107 "Copper Cu 62-ATSM" @default.
- NCIT_C156772 NCIT_P107 "Copper Cu 64-CB-TE1A1P-PEG4-LLP2A" @default.
- NCIT_C156772 NCIT_P108 "Copper Cu 64-CB-TE1A1P-PEG4-LLP2A" @default.
- NCIT_C156772 NCIT_P208 "CL935819" @default.
- NCIT_C156772 NCIT_P322 "CTRP" @default.
- NCIT_C156772 NCIT_P329 "796462" @default.
- NCIT_C156772 NCIT_P330 "796462" @default.
- NCIT_C156772 NCIT_P399 "796462" @default.
- NCIT_C156772 normalizedInformationContent "100" @default.
- NCIT_C156772 referenceCount "1" @default.
- NCIT_C156772 hasExactSynonym "(64)Cu-CB-TE1A1P-PEG4-LLP2A" @default.
- NCIT_C156772 hasExactSynonym "(64)Cu-labeled CB-TE1A1P-PEG4 LLP2A" @default.
- NCIT_C156772 hasExactSynonym "(64)Cu-labeled CB-TE1A1P-PEG4-LLP2A" @default.
- NCIT_C156772 hasExactSynonym "64Cu-CB-TE1A1P-PEG4-LLP2A" @default.
- NCIT_C156772 hasExactSynonym "64Cu-LLP2A" @default.
- NCIT_C156772 hasExactSynonym "64Cu-PEG4-LLP2A" @default.
- NCIT_C156772 hasExactSynonym "Copper Cu 64-CB-TE1A1P-PEG4-LLP2A" @default.
- NCIT_C156772 hasExactSynonym "Copper Cu 64-LLP2A" @default.
- NCIT_C156772 hasExactSynonym "Cu[64]-CB-TE1A1P-PEG4-LLP2A" @default.
- NCIT_C156772 inSubset NCIT_C116977 @default.
- NCIT_C156772 inSubset NCIT_C116978 @default.
- NCIT_C156772 inSubset NCIT_C176424 @default.
- NCIT_C156772 type Class @default.
- NCIT_C156772 isDefinedBy ncit.owl @default.
- NCIT_C156772 label "Copper Cu 64-CB-TE1A1P-PEG4-LLP2A" @default.
- NCIT_C156772 subClassOf NCIT_C1446 @default.
- NCIT_C156772 subClassOf NCIT_C156772 @default.
- NCIT_C156772 subClassOf NCIT_C1908 @default.
- NCIT_C156772 subClassOf NCIT_C1909 @default.
- NCIT_C156772 subClassOf NCIT_C2124 @default.