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- NCIT_C156773 IAO_0000115 "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, the EGFR mutant-specific inhibitor D-0316 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Compared to some other EGFR inhibitors, D-0316 may have therapeutic benefits in tumors with T790M-mediated drug resistance. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C156773 NCIT_NHC0 "C156773" @default.
- NCIT_C156773 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156773 NCIT_P108 "EGFR Mutant-specific Inhibitor D-0316" @default.
- NCIT_C156773 NCIT_P310 "Retired_Concept" @default.
- NCIT_C156773 NCIT_P98 "Wed Sep 29 16:04:57 EDT 2021 - See 'Befotertinib(C175747)'" @default.
- NCIT_C156773 normalizedInformationContent "100" @default.
- NCIT_C156773 referenceCount "1" @default.
- NCIT_C156773 hasExactSynonym "D 0316" @default.
- NCIT_C156773 hasExactSynonym "D-0316" @default.
- NCIT_C156773 hasExactSynonym "D0316" @default.
- NCIT_C156773 hasExactSynonym "EGFR Mutant-specific Inhibitor D-0316" @default.
- NCIT_C156773 type Class @default.
- NCIT_C156773 isDefinedBy ncit.owl @default.
- NCIT_C156773 label "EGFR Mutant-specific Inhibitor D-0316" @default.
- NCIT_C156773 subClassOf NCIT_C156773 @default.
- NCIT_C156773 subClassOf NCIT_C185140 @default.
- NCIT_C156773 subClassOf NCIT_C28428 @default.
- NCIT_C156773 deprecated "true" @default.