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- NCIT_C156777 IAO_0000115 "An orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential antineoplastic activity. Upon administration, farudodstat specifically targets, binds to and prevents the activation of DHODH, thereby preventing the fourth enzymatic step in de novo pyrimidine synthesis. This prevents uridine monophosphate (UMP) formation, DNA synthesis, cell division and cellular proliferation, causes reactive oxygen species (ROS) formation, enables differentiation and induces apoptosis in susceptible tumor cells. DHODH, a mitochondrial enzyme, catalyzes the conversion of dihydroorotate (DHO) to orotate in the endogenous synthesis of UMP." @default.
- NCIT_C156777 NCIT_A7 NCIT_C17289 @default.
- NCIT_C156777 NCIT_NHC0 "C156777" @default.
- NCIT_C156777 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156777 NCIT_P108 "Farudodstat" @default.
- NCIT_C156777 NCIT_P208 "CL935809" @default.
- NCIT_C156777 NCIT_P210 "1035688-66-4" @default.
- NCIT_C156777 NCIT_P319 "I58WE41H6X" @default.
- NCIT_C156777 NCIT_P322 "FDA" @default.
- NCIT_C156777 NCIT_P329 "795787" @default.
- NCIT_C156777 NCIT_P330 "795787" @default.
- NCIT_C156777 NCIT_P399 "795787" @default.
- NCIT_C156777 normalizedInformationContent "100" @default.
- NCIT_C156777 referenceCount "1" @default.
- NCIT_C156777 hasExactSynonym "ASLAN 003" @default.
- NCIT_C156777 hasExactSynonym "ASLAN-003" @default.
- NCIT_C156777 hasExactSynonym "ASLAN003" @default.
- NCIT_C156777 hasExactSynonym "DHODH Inhibitor ASLAN003" @default.
- NCIT_C156777 hasExactSynonym "Dihydroorotate Dehydrogenase Inhibitor ASLAN003" @default.
- NCIT_C156777 hasExactSynonym "FARUDODSTAT" @default.
- NCIT_C156777 hasExactSynonym "Farudodstat" @default.
- NCIT_C156777 inSubset NCIT_C176424 @default.
- NCIT_C156777 inSubset NCIT_C63923 @default.
- NCIT_C156777 type Class @default.
- NCIT_C156777 isDefinedBy ncit.owl @default.
- NCIT_C156777 label "Farudodstat" @default.
- NCIT_C156777 subClassOf NCIT_C156777 @default.
- NCIT_C156777 subClassOf NCIT_C1908 @default.
- NCIT_C156777 subClassOf NCIT_C1909 @default.
- NCIT_C156777 subClassOf NCIT_C2169 @default.
- NCIT_C156777 subClassOf NCIT_C308 @default.
- NCIT_C156777 subClassOf NCIT_C471 @default.
- NCIT_C156777 subClassOf NCIT_C574 @default.