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- NCIT_C156883 IAO_0000115 "A preparation of CD4+ and CD8+ autologous T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) composed of a short chain variable fragment (scFv) binding domain derived from depatuxizumab, a human anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb806; ABT-806), coupled to the zeta chain of the TCR/CD3 complex (CD3-zeta) and the signaling domain of 4-1BB (CD137), and linked to a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Depatuxizumab specifically targets abnormal conformational states of EGFR, including the EGFR deletion mutation variant III (EGFRvIII), and activating mutations, with very low affinity for wild-type EGFR. Upon intravenous administration, the autologous CD4+/CD8+ EGFR806 specific 4-1BB-CD3zeta-EGFRt-expressing CAR T-cells are directed to and induce selective toxicity in EGFRvIII-expressing tumor cells. Devoid of both ligand binding domains and tyrosine kinase activity, the expressed EGFRt both facilitates in vivo detection of the administered, transduced T-cells and can promote elimination of these cells through an anti-EGFR antibody-dependent cellular cytotoxicity (ADCC) response. EGFRvIII, an in-frame deletion of exons 2-7 in the EGFR gene, is overexpressed by a variety of cancer cell types but absent in normal, healthy cells. It plays a key role in tumor cell proliferation, tumor angiogenesis and resistance to both radio- and chemotherapy." @default.
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- NCIT_C156883 NCIT_NHC0 "C156883" @default.
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- NCIT_C156883 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156883 NCIT_P107 "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells" @default.
- NCIT_C156883 NCIT_P108 "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells" @default.
- NCIT_C156883 NCIT_P208 "CL935992" @default.
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- NCIT_C156883 NCIT_P330 "796466" @default.
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- NCIT_C156883 normalizedInformationContent "100" @default.
- NCIT_C156883 referenceCount "1" @default.
- NCIT_C156883 hasExactSynonym "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells" @default.
- NCIT_C156883 hasExactSynonym "Autologous CD4+/CD8+ T Cells Expressing EGFR806-specific CAR/EGFRt" @default.
- NCIT_C156883 hasExactSynonym "Autologous EGFR806 Specific CAR T Cells" @default.
- NCIT_C156883 hasExactSynonym "Autologous EGFR806-specific CAR T Cells" @default.
- NCIT_C156883 inSubset NCIT_C116977 @default.
- NCIT_C156883 inSubset NCIT_C116978 @default.
- NCIT_C156883 inSubset NCIT_C128784 @default.
- NCIT_C156883 inSubset NCIT_C176424 @default.
- NCIT_C156883 type Class @default.
- NCIT_C156883 isDefinedBy ncit.owl @default.
- NCIT_C156883 label "Autologous CD4+/CD8+ EGFR806 Specific 4-1BB-CD3zeta-EGFRt-expressing CAR T Cells" @default.
- NCIT_C156883 subClassOf NCIT_C129820 @default.
- NCIT_C156883 subClassOf NCIT_C129821 @default.
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- NCIT_C156883 subClassOf NCIT_C156883 @default.
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- NCIT_C156883 subClassOf NCIT_C274 @default.
- NCIT_C156883 subClassOf NCIT_C28681 @default.
- NCIT_C156883 subClassOf NCIT_C307 @default.
- NCIT_C156883 subClassOf NCIT_C308 @default.