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- NCIT_C156895 IAO_0000115 "The sulfate salt form of larotrectinib, an orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, larotrectinib binds to Trk, thereby preventing neurotrophin-Trk interaction and Trk activation, which results in both the induction of cellular apoptosis and the inhibition of cell growth in tumors that overexpress Trk. Trk, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival." @default.
- NCIT_C156895 NCIT_A32 NCIT_C1909 @default.
- NCIT_C156895 NCIT_A6 NCIT_C115977 @default.
- NCIT_C156895 NCIT_A7 NCIT_C28558 @default.
- NCIT_C156895 NCIT_A7 NCIT_C33983 @default.
- NCIT_C156895 NCIT_A7 NCIT_C33984 @default.
- NCIT_C156895 NCIT_NHC0 "C156895" @default.
- NCIT_C156895 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C156895 NCIT_P107 "Larotrectinib Sulfate" @default.
- NCIT_C156895 NCIT_P108 "Larotrectinib Sulfate" @default.
- NCIT_C156895 NCIT_P208 "CL935988" @default.
- NCIT_C156895 NCIT_P210 "1223405-08-0" @default.
- NCIT_C156895 NCIT_P302 "solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation" @default.
- NCIT_C156895 NCIT_P319 "RDF76R62ID" @default.
- NCIT_C156895 NCIT_P322 "CTRP" @default.
- NCIT_C156895 NCIT_P322 "FDA" @default.
- NCIT_C156895 NCIT_P322 "GDC" @default.
- NCIT_C156895 NCIT_P329 "760532" @default.
- NCIT_C156895 NCIT_P330 "760532" @default.
- NCIT_C156895 NCIT_P375 "Larotrectinib Sulfate" @default.
- NCIT_C156895 NCIT_P399 "760532" @default.
- NCIT_C156895 normalizedInformationContent "100" @default.
- NCIT_C156895 referenceCount "1" @default.
- NCIT_C156895 hasExactSynonym "(3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide;sulfuric acid" @default.
- NCIT_C156895 hasExactSynonym "1-Pyrrolidinecarboxamide, N-(5-((2R)-2-(2,5-Difluorophenyl)-1-pyrrolidinyl)pyrazolo(1,5-a)pyrimidin-3-yl)-3-hydroxy-, (3S)-, Sulfate (1:1)" @default.
- NCIT_C156895 hasExactSynonym "ARRY 470 Sulfate" @default.
- NCIT_C156895 hasExactSynonym "LAROTRECTINIB SULFATE" @default.
- NCIT_C156895 hasExactSynonym "LOXO 101 Sulfate" @default.
- NCIT_C156895 hasExactSynonym "LOXO-101 Sulfate" @default.
- NCIT_C156895 hasExactSynonym "Larotrectinib Sulfate" @default.
- NCIT_C156895 hasExactSynonym "Vitrakvi" @default.
- NCIT_C156895 inSubset NCIT_C116977 @default.
- NCIT_C156895 inSubset NCIT_C116978 @default.
- NCIT_C156895 inSubset NCIT_C128784 @default.
- NCIT_C156895 inSubset NCIT_C157711 @default.
- NCIT_C156895 inSubset NCIT_C157712 @default.
- NCIT_C156895 inSubset NCIT_C176424 @default.
- NCIT_C156895 inSubset NCIT_C177537 @default.
- NCIT_C156895 inSubset NCIT_C63923 @default.
- NCIT_C156895 type Class @default.
- NCIT_C156895 isDefinedBy ncit.owl @default.
- NCIT_C156895 label "Larotrectinib Sulfate" @default.
- NCIT_C156895 subClassOf NCIT_C129824 @default.
- NCIT_C156895 subClassOf NCIT_C129825 @default.
- NCIT_C156895 subClassOf NCIT_C1404 @default.
- NCIT_C156895 subClassOf NCIT_C155765 @default.
- NCIT_C156895 subClassOf NCIT_C156895 @default.
- NCIT_C156895 subClassOf NCIT_C163758 @default.
- NCIT_C156895 subClassOf NCIT_C1908 @default.
- NCIT_C156895 subClassOf NCIT_C1909 @default.
- NCIT_C156895 subClassOf NCIT_C1967 @default.
- NCIT_C156895 subClassOf NCIT_C2189 @default.
- NCIT_C156895 subClassOf NCIT_C274 @default.
- NCIT_C156895 subClassOf NCIT_C471 @default.