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- NCIT_C157039 IAO_0000115 "An orally available, small-molecule, allosteric activator of the red cell isoform of pyruvate kinase (PK-R), with potential to improve hemolytic anemia in patients with pyruvate kinase deficiency (PKD). Upon oral administration, mitapivat binds to and activates PK-R, thereby enhancing glycolytic pathway activity, improving adenosine triphosphate (ATP) levels and reducing 2,3-diphosphoglycerate (2,3-DPG) levels. Mutations in PK-R cause deficiency in PK-R which prevents adequate red blood cell (RBC) glycolysis, leading to a buildup of the upstream glycolytic intermediate 2,3-DPG and deficiency in the PK-R product ATP." @default.
- NCIT_C157039 NCIT_NHC0 "C157039" @default.
- NCIT_C157039 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157039 NCIT_P107 "Mitapivat" @default.
- NCIT_C157039 NCIT_P108 "Mitapivat" @default.
- NCIT_C157039 NCIT_P208 "CL936034" @default.
- NCIT_C157039 NCIT_P210 "1260075-17-9" @default.
- NCIT_C157039 NCIT_P319 "2WTV10SIKH" @default.
- NCIT_C157039 NCIT_P322 "CTRP" @default.
- NCIT_C157039 NCIT_P322 "FDA" @default.
- NCIT_C157039 NCIT_P329 "796492" @default.
- NCIT_C157039 NCIT_P330 "796492" @default.
- NCIT_C157039 NCIT_P399 "796492" @default.
- NCIT_C157039 normalizedInformationContent "100" @default.
- NCIT_C157039 referenceCount "1" @default.
- NCIT_C157039 hasExactSynonym "AG 348" @default.
- NCIT_C157039 hasExactSynonym "AG-348" @default.
- NCIT_C157039 hasExactSynonym "AG348" @default.
- NCIT_C157039 hasExactSynonym "MITAPIVAT" @default.
- NCIT_C157039 hasExactSynonym "Mitapivat" @default.
- NCIT_C157039 hasExactSynonym "PK-R Activator AG-348" @default.
- NCIT_C157039 hasExactSynonym "PKR-IN-1" @default.
- NCIT_C157039 hasExactSynonym "Red Cell Pyruvate Kinase Activator AG-348" @default.
- NCIT_C157039 inSubset NCIT_C116977 @default.
- NCIT_C157039 inSubset NCIT_C116978 @default.
- NCIT_C157039 inSubset NCIT_C176424 @default.
- NCIT_C157039 inSubset NCIT_C63923 @default.
- NCIT_C157039 type Class @default.
- NCIT_C157039 isDefinedBy ncit.owl @default.
- NCIT_C157039 label "Mitapivat" @default.
- NCIT_C157039 subClassOf NCIT_C157039 @default.
- NCIT_C157039 subClassOf NCIT_C1908 @default.
- NCIT_C157039 subClassOf NCIT_C1909 @default.
- NCIT_C157039 subClassOf NCIT_C78275 @default.