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- NCIT_C157058 IAO_0000115 "A bispecific antibody directed against the inhibitory T-cell receptor T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3; TIM3; hepatitis A virus cellular receptor 2; HAVCR2) and the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, LY3415244 simultaneously targets and binds to TIM-3 expressed on certain T-cells, including tumor-infiltrating lymphocytes (TILs), and PD-L1 expressed on tumor cells. This blocks the interaction of TIM-3 with some of its physiologic ligands and prevents PD-L1 from binding to and activating its receptor, programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1). This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which may lead to a reduction in tumor growth. TIM-3, a transmembrane protein and immune checkpoint receptor, is often co-expressed with PD-1 on tumor-antigen-specific T-cells. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion." @default.
- NCIT_C157058 NCIT_A32 NCIT_C1909 @default.
- NCIT_C157058 NCIT_A7 NCIT_C96024 @default.
- NCIT_C157058 NCIT_NHC0 "C157058" @default.
- NCIT_C157058 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157058 NCIT_P107 "Anti-PD-L1/TIM-3 Bispecific Antibody LY3415244" @default.
- NCIT_C157058 NCIT_P108 "Anti-PD-L1/TIM-3 Bispecific Antibody LY3415244" @default.
- NCIT_C157058 NCIT_P208 "CL936018" @default.
- NCIT_C157058 NCIT_P319 "603H2FWG4N" @default.
- NCIT_C157058 NCIT_P322 "CTRP" @default.
- NCIT_C157058 NCIT_P322 "FDA" @default.
- NCIT_C157058 NCIT_P322 "GDC" @default.
- NCIT_C157058 NCIT_P329 "796576" @default.
- NCIT_C157058 NCIT_P330 "796576" @default.
- NCIT_C157058 NCIT_P375 "Anti-PD-L1/TIM-3 Bispecific Antibody LY3415244" @default.
- NCIT_C157058 NCIT_P399 "796576" @default.
- NCIT_C157058 normalizedInformationContent "100" @default.
- NCIT_C157058 referenceCount "1" @default.
- NCIT_C157058 hasExactSynonym "Anti-PD-L1/TIM-3 Bispecific Antibody LY3415244" @default.
- NCIT_C157058 hasExactSynonym "LY 3415244" @default.
- NCIT_C157058 hasExactSynonym "LY-3415244" @default.
- NCIT_C157058 hasExactSynonym "LY3415244" @default.
- NCIT_C157058 inSubset NCIT_C116977 @default.
- NCIT_C157058 inSubset NCIT_C116978 @default.
- NCIT_C157058 inSubset NCIT_C128784 @default.
- NCIT_C157058 inSubset NCIT_C157711 @default.
- NCIT_C157058 inSubset NCIT_C157712 @default.
- NCIT_C157058 inSubset NCIT_C176424 @default.
- NCIT_C157058 inSubset NCIT_C177537 @default.
- NCIT_C157058 inSubset NCIT_C63923 @default.
- NCIT_C157058 type Class @default.
- NCIT_C157058 isDefinedBy ncit.owl @default.
- NCIT_C157058 label "Anti-PD-L1/TIM-3 Bispecific Antibody LY3415244" @default.
- NCIT_C157058 subClassOf NCIT_C129821 @default.
- NCIT_C157058 subClassOf NCIT_C129822 @default.
- NCIT_C157058 subClassOf NCIT_C1454 @default.
- NCIT_C157058 subClassOf NCIT_C157058 @default.
- NCIT_C157058 subClassOf NCIT_C1908 @default.
- NCIT_C157058 subClassOf NCIT_C1909 @default.
- NCIT_C157058 subClassOf NCIT_C274 @default.
- NCIT_C157058 subClassOf NCIT_C307 @default.
- NCIT_C157058 subClassOf NCIT_C308 @default.