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- NCIT_C157061 IAO_0000115 "A humanized immunoglobulin G1 (IgG1) monoclonal antibody targeting sialic acid binding Ig-like lectin 15 (Siglec-15; SIGLEC15; S15), a member of the sialic acid-binding immunoglobulin type lectins, with potential antineoplastic and immunomodulatory activities. Upon administration, anti-S15 monoclonal antibody NC318 targets and binds to S15 on the surface of tumor-associated macrophages (TAMs) and certain tumor cells. Binding to S15 may disrupt TAM-mediated activities such as promotion of tumor initiation and metastasis of tumor cells, inhibition of T-cell responses, and stimulation of tumor angiogenesis and disease progression. S15, a highly conserved type 1 cell surface protein, normally involved in osteoclast differentiation and bone remodeling, may play a role in the survival and differentiation of TAMs." @default.
- NCIT_C157061 NCIT_A32 NCIT_C1909 @default.
- NCIT_C157061 NCIT_A7 NCIT_C158386 @default.
- NCIT_C157061 NCIT_NHC0 "C157061" @default.
- NCIT_C157061 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C157061 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157061 NCIT_P107 "Anti-S15 Monoclonal Antibody NC318" @default.
- NCIT_C157061 NCIT_P108 "Anti-S15 Monoclonal Antibody NC318" @default.
- NCIT_C157061 NCIT_P208 "CL936043" @default.
- NCIT_C157061 NCIT_P322 "CTRP" @default.
- NCIT_C157061 NCIT_P322 "GDC" @default.
- NCIT_C157061 NCIT_P329 "796496" @default.
- NCIT_C157061 NCIT_P330 "796496" @default.
- NCIT_C157061 NCIT_P375 "Anti-S15 Monoclonal Antibody NC318" @default.
- NCIT_C157061 NCIT_P399 "796496" @default.
- NCIT_C157061 NCIT_R124 NCIT_C17710 @default.
- NCIT_C157061 NCIT_R124 NCIT_C17828 @default.
- NCIT_C157061 NCIT_R124 NCIT_C18219 @default.
- NCIT_C157061 NCIT_R124 NCIT_C19986 @default.
- NCIT_C157061 NCIT_R124 NCIT_C40474 @default.
- NCIT_C157061 normalizedInformationContent "100" @default.
- NCIT_C157061 referenceCount "1" @default.
- NCIT_C157061 hasExactSynonym "Anti-S15 Monoclonal Antibody NC318" @default.
- NCIT_C157061 hasExactSynonym "Anti-S15 mAb NC318" @default.
- NCIT_C157061 hasExactSynonym "Anti-Siglec-15 Monoclonal Antibody NC318" @default.
- NCIT_C157061 hasExactSynonym "NC 318" @default.
- NCIT_C157061 hasExactSynonym "NC-318" @default.
- NCIT_C157061 hasExactSynonym "NC318" @default.
- NCIT_C157061 inSubset NCIT_C116977 @default.
- NCIT_C157061 inSubset NCIT_C116978 @default.
- NCIT_C157061 inSubset NCIT_C128784 @default.
- NCIT_C157061 inSubset NCIT_C157711 @default.
- NCIT_C157061 inSubset NCIT_C157712 @default.
- NCIT_C157061 inSubset NCIT_C176424 @default.
- NCIT_C157061 inSubset NCIT_C177537 @default.
- NCIT_C157061 type Class @default.
- NCIT_C157061 isDefinedBy ncit.owl @default.
- NCIT_C157061 label "Anti-S15 Monoclonal Antibody NC318" @default.
- NCIT_C157061 subClassOf NCIT_C129821 @default.
- NCIT_C157061 subClassOf NCIT_C129822 @default.
- NCIT_C157061 subClassOf NCIT_C157061 @default.
- NCIT_C157061 subClassOf NCIT_C1908 @default.
- NCIT_C157061 subClassOf NCIT_C1909 @default.
- NCIT_C157061 subClassOf NCIT_C20401 @default.
- NCIT_C157061 subClassOf NCIT_C274 @default.
- NCIT_C157061 subClassOf NCIT_C307 @default.
- NCIT_C157061 subClassOf NCIT_C308 @default.