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- NCIT_C157062 IAO_0000115 "A recombinant, humanized, agonistic, tetravalent monoclonal antibody directed against human death receptor type 5 (DR5), also called tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 (TRAILR2), with potential pro-apoptotic and antineoplastic activities. Upon administration, INBRX-109 specifically binds to exactly four DR5 receptors per molecule, which mimics the interaction of DR5 with its natural ligand TRAIL. This activates DR5 and the death receptor signaling pathway, which results in the activation of caspase cascades, the induction of tumor cell apoptosis and a reduction in proliferation of DR5-expressing tumor cells. Utilizing a tetravalent monoclonal antibody may overcome the challenge of generating effective DR5 clustering while avoiding toxicities associated with anti-drug antibody (ADA) hyper-clustering. DR5, a member of the TNF receptor superfamily (TNFRSF), is expressed on the surfaces of a variety of tumor cells and plays a key role in the induction of tumor cell apoptosis." @default.
- NCIT_C157062 NCIT_A32 NCIT_C1909 @default.
- NCIT_C157062 NCIT_A7 NCIT_C18178 @default.
- NCIT_C157062 NCIT_NHC0 "C157062" @default.
- NCIT_C157062 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C157062 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157062 NCIT_P107 "Anti-DR5 Agonistic Monoclonal Antibody INBRX-109" @default.
- NCIT_C157062 NCIT_P108 "Anti-DR5 Agonistic Monoclonal Antibody INBRX-109" @default.
- NCIT_C157062 NCIT_P208 "CL936041" @default.
- NCIT_C157062 NCIT_P322 "CTRP" @default.
- NCIT_C157062 NCIT_P322 "GDC" @default.
- NCIT_C157062 NCIT_P329 "796494" @default.
- NCIT_C157062 NCIT_P330 "796494" @default.
- NCIT_C157062 NCIT_P375 "Anti-DR5 Agonistic Monoclonal Antibody INBRX-109" @default.
- NCIT_C157062 NCIT_P399 "796494" @default.
- NCIT_C157062 NCIT_R124 NCIT_C17710 @default.
- NCIT_C157062 NCIT_R124 NCIT_C17828 @default.
- NCIT_C157062 NCIT_R124 NCIT_C18219 @default.
- NCIT_C157062 NCIT_R124 NCIT_C19986 @default.
- NCIT_C157062 NCIT_R124 NCIT_C40474 @default.
- NCIT_C157062 normalizedInformationContent "100" @default.
- NCIT_C157062 referenceCount "1" @default.
- NCIT_C157062 hasExactSynonym "Anti-DR5 Agonistic Monoclonal Antibody INBRX-109" @default.
- NCIT_C157062 hasExactSynonym "INBRX 109" @default.
- NCIT_C157062 hasExactSynonym "INBRX-109" @default.
- NCIT_C157062 hasExactSynonym "INBRX109" @default.
- NCIT_C157062 inSubset NCIT_C116977 @default.
- NCIT_C157062 inSubset NCIT_C116978 @default.
- NCIT_C157062 inSubset NCIT_C128784 @default.
- NCIT_C157062 inSubset NCIT_C157711 @default.
- NCIT_C157062 inSubset NCIT_C157712 @default.
- NCIT_C157062 inSubset NCIT_C176424 @default.
- NCIT_C157062 inSubset NCIT_C177537 @default.
- NCIT_C157062 type Class @default.
- NCIT_C157062 isDefinedBy ncit.owl @default.
- NCIT_C157062 label "Anti-DR5 Agonistic Monoclonal Antibody INBRX-109" @default.
- NCIT_C157062 subClassOf NCIT_C157062 @default.
- NCIT_C157062 subClassOf NCIT_C1908 @default.
- NCIT_C157062 subClassOf NCIT_C1909 @default.
- NCIT_C157062 subClassOf NCIT_C20401 @default.
- NCIT_C157062 subClassOf NCIT_C307 @default.
- NCIT_C157062 subClassOf NCIT_C308 @default.