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- NCIT_C157257 IAO_0000115 "An immunoglobulin Fc-modified bispecific monoclonal antibody against the tumor-associated antigen (TAA) CD123 and the human T-cell surface antigen CD3 bispecific monoclonal antibody, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-CD123/CD3 monoclonal antibody APVO436 simultaneously binds to both CD3-expressing T-cells and CD123-expressing cancer cells, thereby crosslinking CD123-expressing tumor cells and cytotoxic T-lymphocytes (CTLs). This results in the activation and proliferation of T-cells and causes CTL-mediated cell lysis of CD123-expressing tumor cells. CD123, the interleukin-3 receptor alpha chain, is overexpressed in a variety of hematological malignancies; its expression is low or absent in normal hematopoietic progenitors and stem cells. The Fc domain on the antibody prolongs the half-life of the bispecific antibody. Compared to some other CD123 x CD3 targeting bispecific antibodies, APVO436 causes less cytokine release upon T-cell stimulation." @default.
- NCIT_C157257 NCIT_A32 NCIT_C1909 @default.
- NCIT_C157257 NCIT_A7 NCIT_C39275 @default.
- NCIT_C157257 NCIT_NHC0 "C157257" @default.
- NCIT_C157257 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C157257 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157257 NCIT_P107 "Anti-CD123/CD3 Bispecific Antibody APVO436" @default.
- NCIT_C157257 NCIT_P108 "Anti-CD123/CD3 Bispecific Antibody APVO436" @default.
- NCIT_C157257 NCIT_P208 "CL936868" @default.
- NCIT_C157257 NCIT_P319 "DNP8BBW84R" @default.
- NCIT_C157257 NCIT_P322 "CTRP" @default.
- NCIT_C157257 NCIT_P322 "FDA" @default.
- NCIT_C157257 NCIT_P322 "GDC" @default.
- NCIT_C157257 NCIT_P329 "796808" @default.
- NCIT_C157257 NCIT_P330 "796808" @default.
- NCIT_C157257 NCIT_P375 "Anti-CD123/CD3 Bispecific Antibody APVO436" @default.
- NCIT_C157257 NCIT_P399 "796808" @default.
- NCIT_C157257 NCIT_R124 NCIT_C17710 @default.
- NCIT_C157257 NCIT_R124 NCIT_C17828 @default.
- NCIT_C157257 NCIT_R124 NCIT_C18219 @default.
- NCIT_C157257 NCIT_R124 NCIT_C19986 @default.
- NCIT_C157257 NCIT_R124 NCIT_C40474 @default.
- NCIT_C157257 normalizedInformationContent "100" @default.
- NCIT_C157257 referenceCount "1" @default.
- NCIT_C157257 hasExactSynonym "APVO 436" @default.
- NCIT_C157257 hasExactSynonym "APVO-436" @default.
- NCIT_C157257 hasExactSynonym "APVO436" @default.
- NCIT_C157257 hasExactSynonym "Anti-CD123 x Anti-CD3 Bispecific Antibody APVO436" @default.
- NCIT_C157257 hasExactSynonym "Anti-CD123/CD3 Bispecific Antibody APVO436" @default.
- NCIT_C157257 hasExactSynonym "Bispecific Anti-CD123 x Anti-CD3 Antibody APVO436" @default.
- NCIT_C157257 hasExactSynonym "CD123 x CD3 Targeting Bispecific Antibody APVO436" @default.
- NCIT_C157257 inSubset NCIT_C116977 @default.
- NCIT_C157257 inSubset NCIT_C116978 @default.
- NCIT_C157257 inSubset NCIT_C128784 @default.
- NCIT_C157257 inSubset NCIT_C157711 @default.
- NCIT_C157257 inSubset NCIT_C157712 @default.
- NCIT_C157257 inSubset NCIT_C176424 @default.
- NCIT_C157257 inSubset NCIT_C177537 @default.
- NCIT_C157257 inSubset NCIT_C63923 @default.
- NCIT_C157257 type Class @default.
- NCIT_C157257 isDefinedBy ncit.owl @default.
- NCIT_C157257 label "Anti-CD123/CD3 Bispecific Antibody APVO436" @default.
- NCIT_C157257 subClassOf NCIT_C112883 @default.
- NCIT_C157257 subClassOf NCIT_C129821 @default.
- NCIT_C157257 subClassOf NCIT_C129822 @default.
- NCIT_C157257 subClassOf NCIT_C1454 @default.
- NCIT_C157257 subClassOf NCIT_C157257 @default.
- NCIT_C157257 subClassOf NCIT_C1908 @default.
- NCIT_C157257 subClassOf NCIT_C1909 @default.
- NCIT_C157257 subClassOf NCIT_C201282 @default.
- NCIT_C157257 subClassOf NCIT_C201511 @default.
- NCIT_C157257 subClassOf NCIT_C20401 @default.
- NCIT_C157257 subClassOf NCIT_C274 @default.
- NCIT_C157257 subClassOf NCIT_C28227 @default.
- NCIT_C157257 subClassOf NCIT_C307 @default.
- NCIT_C157257 subClassOf NCIT_C308 @default.