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- NCIT_C157281 IAO_0000115 "Autologous T-lymphocytes transduced with a lentiviral vector expressing a compound chimeric antigen receptor (cCAR) containing two CARs, one specific for the CD33 antigen and one specific for the C-type-lectin-like molecule-1 (CLL1; C-type lectin domain family 12 member A; CLEC12A), with potential immunomodulating and antineoplastic activities. Upon administration, the CD33/CLL1-specific CARs lentiviral vector-transduced autologous T-lymphocytes, expressing both the anti-CD33 CAR and the anti-CLL1 CAR on their surfaces, specifically and simultaneously target and bind to CD33- and CLL1-expressing tumor cells, with their anti-CD33 CAR and their anti-CLL1 CAR, respectively. This induces selective toxicity in tumor cells that express the CD33 antigen and the CLL1 antigen. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells. CLL1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse for myeloid malignancies." @default.
- NCIT_C157281 NCIT_NHC0 "C157281" @default.
- NCIT_C157281 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157281 NCIT_P108 "Autologous CLL1-CD33 Compound CAR T Cells" @default.
- NCIT_C157281 NCIT_P208 "CL937014" @default.
- NCIT_C157281 NCIT_P329 "796670" @default.
- NCIT_C157281 NCIT_P330 "796670" @default.
- NCIT_C157281 NCIT_P399 "796670" @default.
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- NCIT_C157281 hasExactSynonym "Autologous Anti-CLL1/Anti-CD33 CARs-expressing T-lymphocytes" @default.
- NCIT_C157281 hasExactSynonym "Autologous CLL1-CD33 Compound CAR T Cells" @default.
- NCIT_C157281 hasExactSynonym "Autologous CLL1-CD33 cCAR T Cells" @default.
- NCIT_C157281 hasExactSynonym "Autologous CLL1-CD33 cCAR T-lymphocytes" @default.
- NCIT_C157281 hasExactSynonym "Autologous CLL1-CD33 cCAR" @default.
- NCIT_C157281 inSubset NCIT_C128784 @default.
- NCIT_C157281 inSubset NCIT_C176424 @default.
- NCIT_C157281 type Class @default.
- NCIT_C157281 isDefinedBy ncit.owl @default.
- NCIT_C157281 label "Autologous CLL1-CD33 Compound CAR T Cells" @default.
- NCIT_C157281 subClassOf NCIT_C129820 @default.
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