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- NCIT_C157385 IAO_0000115 "A human immunoglobulin G4 (IgG4) monoclonal antibody targeting leukocyte surface antigen CD47 with potential immunostimulating and antineoplastic activities. Upon intravenous administration, letaplimab selectively binds to CD47 expressed on tumor cells and blocks the interaction of CD47 with signal regulatory protein alpha (SIRPa), a protein expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages. This results in macrophage activation and the specific phagocytosis of tumor cells. In addition, blocking CD47 signaling activates both an anti-tumor T-lymphocyte immune response and T cell-mediated killing of CD47-expressing tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate." @default.
- NCIT_C157385 NCIT_A32 NCIT_C1909 @default.
- NCIT_C157385 NCIT_A7 NCIT_C25795 @default.
- NCIT_C157385 NCIT_NHC0 "C157385" @default.
- NCIT_C157385 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C157385 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C157385 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157385 NCIT_P107 "Letaplimab" @default.
- NCIT_C157385 NCIT_P108 "Letaplimab" @default.
- NCIT_C157385 NCIT_P208 "CL936985" @default.
- NCIT_C157385 NCIT_P210 "2283356-07-8" @default.
- NCIT_C157385 NCIT_P319 "BDN84I1TFE" @default.
- NCIT_C157385 NCIT_P322 "CTRP" @default.
- NCIT_C157385 NCIT_P322 "FDA" @default.
- NCIT_C157385 NCIT_P322 "GDC" @default.
- NCIT_C157385 NCIT_P329 "797112" @default.
- NCIT_C157385 NCIT_P330 "797112" @default.
- NCIT_C157385 NCIT_P375 "Anti-CD47 Monoclonal Antibody IBI188" @default.
- NCIT_C157385 NCIT_P399 "797112" @default.
- NCIT_C157385 NCIT_R124 NCIT_C17710 @default.
- NCIT_C157385 NCIT_R124 NCIT_C17828 @default.
- NCIT_C157385 NCIT_R124 NCIT_C18219 @default.
- NCIT_C157385 NCIT_R124 NCIT_C19986 @default.
- NCIT_C157385 NCIT_R124 NCIT_C40474 @default.
- NCIT_C157385 normalizedInformationContent "100" @default.
- NCIT_C157385 referenceCount "1" @default.
- NCIT_C157385 hasExactSynonym "Anti-CD47 Monoclonal Antibody IBI188" @default.
- NCIT_C157385 hasExactSynonym "IBI 188" @default.
- NCIT_C157385 hasExactSynonym "IBI-188" @default.
- NCIT_C157385 hasExactSynonym "IBI188" @default.
- NCIT_C157385 hasExactSynonym "LETAPLIMAB" @default.
- NCIT_C157385 hasExactSynonym "Letaplimab" @default.
- NCIT_C157385 inSubset NCIT_C116977 @default.
- NCIT_C157385 inSubset NCIT_C116978 @default.
- NCIT_C157385 inSubset NCIT_C128784 @default.
- NCIT_C157385 inSubset NCIT_C157711 @default.
- NCIT_C157385 inSubset NCIT_C157712 @default.
- NCIT_C157385 inSubset NCIT_C176424 @default.
- NCIT_C157385 inSubset NCIT_C177537 @default.
- NCIT_C157385 inSubset NCIT_C63923 @default.
- NCIT_C157385 type Class @default.
- NCIT_C157385 isDefinedBy ncit.owl @default.
- NCIT_C157385 label "Letaplimab" @default.
- NCIT_C157385 subClassOf Ba43c004b45fbeebf2645f2b1b3536c3a @default.
- NCIT_C157385 subClassOf Ba4eef12f601649d44d53f19e7bd7ff20 @default.
- NCIT_C157385 subClassOf NCIT_C129821 @default.
- NCIT_C157385 subClassOf NCIT_C129822 @default.
- NCIT_C157385 subClassOf NCIT_C157385 @default.
- NCIT_C157385 subClassOf NCIT_C159583 @default.
- NCIT_C157385 subClassOf NCIT_C163758 @default.
- NCIT_C157385 subClassOf NCIT_C1908 @default.
- NCIT_C157385 subClassOf NCIT_C1909 @default.
- NCIT_C157385 subClassOf NCIT_C192655 @default.
- NCIT_C157385 subClassOf NCIT_C20401 @default.
- NCIT_C157385 subClassOf NCIT_C274 @default.
- NCIT_C157385 subClassOf NCIT_C307 @default.
- NCIT_C157385 subClassOf NCIT_C308 @default.