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- NCIT_C157405 IAO_0000115 "A fixed combination of abacavir sulfate, a nucleoside reverse transcriptase inhibitor (NRTI) analog of guanosine and lamivudine, an NRTI analog of cytidine, that is used to treat human immunodeficiency virus (HIV) infection. Upon oral administration, abacavir and lamivudine are phosphorylated into active metabolites that compete for incorporation into viral DNA. These metabolites inhibit the HIV reverse transcriptase (RT) enzyme competitively and act as a chain terminator of DNA synthesis. This interferes with the generation of DNA copies of viral RNA, which is necessary for the synthesis of new virions." @default.
- NCIT_C157405 NCIT_NHC0 "C157405" @default.
- NCIT_C157405 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157405 NCIT_P108 "Abacavir Sulfate/Lamivudine" @default.
- NCIT_C157405 NCIT_P207 "C1613391" @default.
- NCIT_C157405 normalizedInformationContent "100" @default.
- NCIT_C157405 referenceCount "1" @default.
- NCIT_C157405 hasExactSynonym "ABC/3TC" @default.
- NCIT_C157405 hasExactSynonym "Abacavir Sulfate/Lamivudine" @default.
- NCIT_C157405 hasExactSynonym "Abacavir/Lamivudine" @default.
- NCIT_C157405 hasExactSynonym "Epzicom" @default.
- NCIT_C157405 hasExactSynonym "Kivexa" @default.
- NCIT_C157405 type Class @default.
- NCIT_C157405 isDefinedBy ncit.owl @default.
- NCIT_C157405 label "Abacavir Sulfate/Lamivudine" @default.
- NCIT_C157405 subClassOf NCIT_C157405 @default.
- NCIT_C157405 subClassOf NCIT_C1589 @default.
- NCIT_C157405 subClassOf NCIT_C1660 @default.
- NCIT_C157405 subClassOf NCIT_C1908 @default.
- NCIT_C157405 subClassOf NCIT_C1909 @default.
- NCIT_C157405 subClassOf NCIT_C254 @default.
- NCIT_C157405 subClassOf NCIT_C281 @default.
- NCIT_C157405 subClassOf NCIT_C471 @default.