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- NCIT_C157408 IAO_0000115 "A fixed combination of emtricitabine, a nucleoside reverse transcriptase (RT) inhibitor (NRTI) analog of cytidine; rilpivirine, a non-nucleoside RT inhibitor (NNRTI); and tenofovir disoproxil fumarate, an NRTI analog of adenosine monophosphate, that is used to treat human immunodeficiency virus (HIV) infection. Upon oral administration, rilpivirine binds to HIV RT, thereby blocking RNA and DNA-dependent DNA polymerase activities including viral replication. Emtricitabine and tenofovir disoproxil fumarate inhibit the activity of HIV RT by competing with natural deoxyribonucleosides for incorporation into the growing viral DNA chain resulting in early chain termination. This interferes with the generation of DNA copies of viral RNA, which is necessary for the synthesis of new virions." @default.
- NCIT_C157408 NCIT_NHC0 "C157408" @default.
- NCIT_C157408 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157408 NCIT_P108 "Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate" @default.
- NCIT_C157408 NCIT_P207 "C3244537" @default.
- NCIT_C157408 normalizedInformationContent "100" @default.
- NCIT_C157408 referenceCount "1" @default.
- NCIT_C157408 hasExactSynonym "Complera" @default.
- NCIT_C157408 hasExactSynonym "Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate" @default.
- NCIT_C157408 hasExactSynonym "Emtricitabine/Rilpivirine/Tenofovir" @default.
- NCIT_C157408 hasExactSynonym "Eviplera" @default.
- NCIT_C157408 hasExactSynonym "FTC/RPV/TDF" @default.
- NCIT_C157408 type Class @default.
- NCIT_C157408 isDefinedBy ncit.owl @default.
- NCIT_C157408 label "Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate" @default.
- NCIT_C157408 subClassOf NCIT_C157408 @default.
- NCIT_C157408 subClassOf NCIT_C1589 @default.
- NCIT_C157408 subClassOf NCIT_C1660 @default.
- NCIT_C157408 subClassOf NCIT_C1908 @default.
- NCIT_C157408 subClassOf NCIT_C1909 @default.
- NCIT_C157408 subClassOf NCIT_C254 @default.
- NCIT_C157408 subClassOf NCIT_C281 @default.
- NCIT_C157408 subClassOf NCIT_C471 @default.