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- NCIT_C157485 IAO_0000115 "A human immunoglobulin G4 (IgG4) monoclonal antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, pimivalimab targets, binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells and T-cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity." @default.
- NCIT_C157485 NCIT_A32 NCIT_C1909 @default.
- NCIT_C157485 NCIT_A7 NCIT_C94697 @default.
- NCIT_C157485 NCIT_NHC0 "C157485" @default.
- NCIT_C157485 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157485 NCIT_P107 "Pimivalimab" @default.
- NCIT_C157485 NCIT_P108 "Pimivalimab" @default.
- NCIT_C157485 NCIT_P208 "CL937077" @default.
- NCIT_C157485 NCIT_P210 "2293951-22-9" @default.
- NCIT_C157485 NCIT_P319 "MA05AF40UO" @default.
- NCIT_C157485 NCIT_P322 "CTRP" @default.
- NCIT_C157485 NCIT_P322 "FDA" @default.
- NCIT_C157485 NCIT_P322 "GDC" @default.
- NCIT_C157485 NCIT_P329 "796722" @default.
- NCIT_C157485 NCIT_P330 "796722" @default.
- NCIT_C157485 NCIT_P375 "Anti-PD-1 Monoclonal Antibody JTX-4014" @default.
- NCIT_C157485 NCIT_P399 "796722" @default.
- NCIT_C157485 NCIT_R124 NCIT_C17710 @default.
- NCIT_C157485 NCIT_R124 NCIT_C17828 @default.
- NCIT_C157485 NCIT_R124 NCIT_C18219 @default.
- NCIT_C157485 NCIT_R124 NCIT_C19986 @default.
- NCIT_C157485 NCIT_R124 NCIT_C40474 @default.
- NCIT_C157485 normalizedInformationContent "100" @default.
- NCIT_C157485 referenceCount "1" @default.
- NCIT_C157485 hasExactSynonym "Anti-PD-1 Monoclonal Antibody JTX-4014" @default.
- NCIT_C157485 hasExactSynonym "JTX 4014" @default.
- NCIT_C157485 hasExactSynonym "JTX-4014" @default.
- NCIT_C157485 hasExactSynonym "JTX4014" @default.
- NCIT_C157485 hasExactSynonym "PIMIVALIMAB" @default.
- NCIT_C157485 hasExactSynonym "Pimivalimab" @default.
- NCIT_C157485 inSubset NCIT_C116977 @default.
- NCIT_C157485 inSubset NCIT_C116978 @default.
- NCIT_C157485 inSubset NCIT_C128784 @default.
- NCIT_C157485 inSubset NCIT_C157711 @default.
- NCIT_C157485 inSubset NCIT_C157712 @default.
- NCIT_C157485 inSubset NCIT_C176424 @default.
- NCIT_C157485 inSubset NCIT_C177537 @default.
- NCIT_C157485 inSubset NCIT_C63923 @default.
- NCIT_C157485 type Class @default.
- NCIT_C157485 isDefinedBy ncit.owl @default.
- NCIT_C157485 label "Pimivalimab" @default.
- NCIT_C157485 subClassOf NCIT_C124946 @default.
- NCIT_C157485 subClassOf NCIT_C128037 @default.
- NCIT_C157485 subClassOf NCIT_C129821 @default.
- NCIT_C157485 subClassOf NCIT_C129822 @default.
- NCIT_C157485 subClassOf NCIT_C141144 @default.
- NCIT_C157485 subClassOf NCIT_C143250 @default.
- NCIT_C157485 subClassOf NCIT_C157485 @default.
- NCIT_C157485 subClassOf NCIT_C163758 @default.
- NCIT_C157485 subClassOf NCIT_C1908 @default.
- NCIT_C157485 subClassOf NCIT_C1909 @default.
- NCIT_C157485 subClassOf NCIT_C20401 @default.
- NCIT_C157485 subClassOf NCIT_C274 @default.
- NCIT_C157485 subClassOf NCIT_C307 @default.
- NCIT_C157485 subClassOf NCIT_C308 @default.