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- NCIT_C157488 IAO_0000115 "A preparation of autologous cytotoxic T-lymphocytes (CTLs) that are specifically reactive to Epstein-Barr virus (EBV) latent membrane protein-2A (LMP-2A) and expressing the co-stimulatory domain 4-1BB (CD137), with potential antineoplastic activity. Upon administration of the EBV/LMP-2A-specific autologous CD8+ T-cells to patients with EBV-positive tumors, these cells bind to and cause cell death in EBV-infected cells. This inhibits proliferation of EBV LMP-2A-expressing tumor cells. EBV LMP-2A is expressed in various malignancies and plays a key role in tumor cell proliferation and survival. 4-1BB, an inducible costimulatory member of the tumor-necrosis factor receptor (TNFR) family, is expressed on activated T-cells. It activates additional CD8+ T-cells, prevents activation-induced cell death of CD8+ T-cells, and selectively induces T-helper 1 (Th1)-type cytokines such as interferon (IFN)-gamma and tumor-necrosis factor-alpha (TNF-alpha)." @default.
- NCIT_C157488 NCIT_NHC0 "C157488" @default.
- NCIT_C157488 NCIT_P106 "Cell" @default.
- NCIT_C157488 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157488 NCIT_P108 "EBV LMP-2A-specific Autologous CD8+ T-cells" @default.
- NCIT_C157488 NCIT_P208 "CL937073" @default.
- NCIT_C157488 NCIT_P329 "796750" @default.
- NCIT_C157488 NCIT_P330 "796750" @default.
- NCIT_C157488 NCIT_P399 "796750" @default.
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- NCIT_C157488 referenceCount "1" @default.
- NCIT_C157488 hasExactSynonym "EBV LMP-2A-specific Autologous CD8+ T-cells" @default.
- NCIT_C157488 hasExactSynonym "EBV Latent Membrane Protein-2a Specific Eutil Autologous Blood-derived T-Lymphocytes" @default.
- NCIT_C157488 hasExactSynonym "EBV-induced Natural T-cells" @default.
- NCIT_C157488 hasExactSynonym "EBV-induced T-lymphocytes" @default.
- NCIT_C157488 hasExactSynonym "EBV/LMP-2A-specific CD8 T-Cells" @default.
- NCIT_C157488 hasExactSynonym "EBViNT Cell" @default.
- NCIT_C157488 hasExactSynonym "EBViNT" @default.
- NCIT_C157488 hasExactSynonym "Epstein-Barr Virus Induced Natural T-cells" @default.
- NCIT_C157488 hasExactSynonym "Eutil Autologous T-lymphocytes" @default.
- NCIT_C157488 inSubset NCIT_C176424 @default.
- NCIT_C157488 type Class @default.
- NCIT_C157488 isDefinedBy ncit.owl @default.
- NCIT_C157488 label "EBV LMP-2A-specific Autologous CD8+ T-cells" @default.
- NCIT_C157488 subClassOf NCIT_C142078 @default.
- NCIT_C157488 subClassOf NCIT_C157488 @default.
- NCIT_C157488 subClassOf NCIT_C1908 @default.
- NCIT_C157488 subClassOf NCIT_C1909 @default.
- NCIT_C157488 subClassOf NCIT_C28681 @default.
- NCIT_C157488 subClassOf NCIT_C307 @default.
- NCIT_C157488 subClassOf NCIT_C308 @default.