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- NCIT_C157493 IAO_0000115 "An orally available, small molecule inhibitor that targets the oncogenic KRAS substitution mutation, G12C, with potential antineoplastic activity. Upon oral administration adagrasib covalently binds to cytosine 12 within the switch II pocket of GDP-bound KRAS G12C, thereby inhibiting mutant KRAS-dependent signaling. KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling, division and differentiation. Mutations of KRAS may induce constitutive signal transduction leading to tumor cell growth, proliferation, invasion, and metastasis." @default.
- NCIT_C157493 NCIT_A32 NCIT_C1909 @default.
- NCIT_C157493 NCIT_A7 NCIT_C98365 @default.
- NCIT_C157493 NCIT_NHC0 "C157493" @default.
- NCIT_C157493 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157493 NCIT_P107 "Adagrasib" @default.
- NCIT_C157493 NCIT_P108 "Adagrasib" @default.
- NCIT_C157493 NCIT_P208 "CL937069" @default.
- NCIT_C157493 NCIT_P210 "2326521-71-3" @default.
- NCIT_C157493 NCIT_P302 "for adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC)." @default.
- NCIT_C157493 NCIT_P319 "8EOO6HQF8Y" @default.
- NCIT_C157493 NCIT_P322 "CTRP" @default.
- NCIT_C157493 NCIT_P322 "FDA" @default.
- NCIT_C157493 NCIT_P322 "GDC" @default.
- NCIT_C157493 NCIT_P329 "796791" @default.
- NCIT_C157493 NCIT_P330 "796791" @default.
- NCIT_C157493 NCIT_P375 "KRAS G12C Inhibitor MRTX849" @default.
- NCIT_C157493 NCIT_P399 "796791" @default.
- NCIT_C157493 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C157493 referenceCount "2" @default.
- NCIT_C157493 hasExactSynonym "ADAGRASIB" @default.
- NCIT_C157493 hasExactSynonym "Adagrasib" @default.
- NCIT_C157493 hasExactSynonym "KRAS G12C Inhibitor MRTX849" @default.
- NCIT_C157493 hasExactSynonym "Krazati" @default.
- NCIT_C157493 hasExactSynonym "MRTX 849" @default.
- NCIT_C157493 hasExactSynonym "MRTX-849" @default.
- NCIT_C157493 hasExactSynonym "MRTX849" @default.
- NCIT_C157493 inSubset NCIT_C116977 @default.
- NCIT_C157493 inSubset NCIT_C116978 @default.
- NCIT_C157493 inSubset NCIT_C128784 @default.
- NCIT_C157493 inSubset NCIT_C157711 @default.
- NCIT_C157493 inSubset NCIT_C157712 @default.
- NCIT_C157493 inSubset NCIT_C176424 @default.
- NCIT_C157493 inSubset NCIT_C177537 @default.
- NCIT_C157493 inSubset NCIT_C63923 @default.
- NCIT_C157493 type Class @default.
- NCIT_C157493 isDefinedBy ncit.owl @default.
- NCIT_C157493 label "Adagrasib" @default.
- NCIT_C157493 subClassOf NCIT_C157493 @default.
- NCIT_C157493 subClassOf NCIT_C163758 @default.
- NCIT_C157493 subClassOf NCIT_C1902 @default.
- NCIT_C157493 subClassOf NCIT_C1908 @default.
- NCIT_C157493 subClassOf NCIT_C1909 @default.
- NCIT_C157493 subClassOf NCIT_C200729 @default.
- NCIT_C157493 subClassOf NCIT_C2189 @default.
- NCIT_C157493 subClassOf NCIT_C274 @default.