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- NCIT_C157536 IAO_0000115 "A fixed combination of darunavir, an inhibitor of the human immunodeficiency virus (HIV) protease; and cobicistat, a cytochrome P450 3A (CYP3A) inhibitor that may be used to treat HIV infection. Upon oral administration, darunavir binds to and inhibits the dimerization and catalytic activity of the HIV aspartyl protease. This inhibits the cleavage of HIV-encoded Gag and Gag-Pol polyproteins in virus-infected cells, which prevents the formation of mature infectious virions. Cobicistat inhibits CYP3A, thereby limiting the metabolism of darunavir and increases its systemic exposure." @default.
- NCIT_C157536 NCIT_NHC0 "C157536" @default.
- NCIT_C157536 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157536 NCIT_P108 "Darunavir/Cobicistat" @default.
- NCIT_C157536 NCIT_P207 "C3871454" @default.
- NCIT_C157536 normalizedInformationContent "100" @default.
- NCIT_C157536 referenceCount "1" @default.
- NCIT_C157536 hasExactSynonym "DRV/COBI" @default.
- NCIT_C157536 hasExactSynonym "Darunavir/Cobicistat" @default.
- NCIT_C157536 hasExactSynonym "Prezcobix" @default.
- NCIT_C157536 hasExactSynonym "Rezolsta" @default.
- NCIT_C157536 inSubset NCIT_C173381 @default.
- NCIT_C157536 inSubset NCIT_C173383 @default.
- NCIT_C157536 type Class @default.
- NCIT_C157536 isDefinedBy ncit.owl @default.
- NCIT_C157536 label "Darunavir/Cobicistat" @default.
- NCIT_C157536 subClassOf NCIT_C157536 @default.
- NCIT_C157536 subClassOf NCIT_C1660 @default.
- NCIT_C157536 subClassOf NCIT_C1908 @default.
- NCIT_C157536 subClassOf NCIT_C1909 @default.
- NCIT_C157536 subClassOf NCIT_C254 @default.
- NCIT_C157536 subClassOf NCIT_C281 @default.
- NCIT_C157536 subClassOf NCIT_C471 @default.
- NCIT_C157536 subClassOf NCIT_C783 @default.
- NCIT_C157536 subClassOf NCIT_C97366 @default.